The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Cancer Letters
T TateishiS Kobayashi

Abstract

We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

References

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Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P BaccanariT Spector
Aug 15, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·T TateishiS Kobayashi

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