The activity of drugs against Giardia intestinalis in neonatal mice

The Journal of Antimicrobial Chemotherapy
P F BorehamR W Shepherd

Abstract

The activities of 12 5-nitroimidazoles and ten other compounds have been compared against Giardia intestinalis stock BRIS/83/HEPU/106 in a suckling mouse model. Ronidazole, satranidazole and fexinidazole were the most active compounds being 2.8, 2.0 and 2.0 times more active than tinidazole respectively and warrant further investigation as potential chemotherapeutic agents. The results obtained in mice are consistent with the known activity of nitroimidazoles in man. There was a strong positive correlation between these results and previous in-vitro studies obtained using a 3H-thymidine uptake assay, indicating that in-vitro studies are of value in predicting in-vivo responses.

Citations

Jul 1, 1994·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·N ChenP Upcroft
Feb 1, 1989·International Journal for Parasitology·A G CaponP G Bundesen
Aug 1, 1993·International Journal for Parasitology·J A UpcroftP Upcroft
May 1, 1995·International Journal for Parasitology·M D FarbeyR C Thompson
Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·P F Boreham, J A Upcroft
Jun 1, 1995·Molecular and Biochemical Parasitology·D M BrownP Upcroft
Dec 20, 1996·Molecular and Biochemical Parasitology·D M BrownP Upcroft
Mar 18, 1999·Molecular and Biochemical Parasitology·D M BrownP Upcroft
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T E NashT A Moore
Oct 1, 1996·European Journal of Biochemistry·D M BrownP Upcroft
May 1, 1994·The Journal of Eukaryotic Microbiology·J A Upcroft, P Upcroft
Jun 5, 1998·Australian Veterinary Journal·L J FilippichJ A Upcroft
Jun 5, 1998·Australian Veterinary Journal·R B Atwell, R H Sutton
Mar 11, 2006·Journal of Biomedical Optics·Justin A RossHalina Rubinsztein-Dunlop
Aug 10, 2011·Antimicrobial Agents and Chemotherapy·Noa Tejman-YardenLars Eckmann
Jan 14, 2012·Veterinary Parasitology·Ruth FiechterManuela Schnyder
Jun 6, 2015·Molecular and Biochemical Parasitology·Samantha J EmeryPaul A Haynes
Aug 19, 2007·Expert Opinion on Pharmacotherapy·Angel A Escobedo, Sergio Cimerman
Jan 26, 2011·Journal of Microbiological Methods·Jiri GutJames H McKerrow
Sep 2, 2016·Journal of the American Veterinary Medical Association·Meriam N SalehAnne M Zajac
Sep 7, 2004·The Journal of Antimicrobial Chemotherapy·Raúl Argüello-GarcíaGuadalupe Ortega-Pierres
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·R W Shepherd, P F Boreham

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