PMID: 697751Jul 15, 1978Paper

The activity of glucagon-stimulated adenylate cyclase from rat liver plasma membranes is modulated by the fluidity of its lipid environment

The Biochemical Journal
I Dipple, M D Houslay

Abstract

1. The local anaesthetic benzyl alcohol progressively activated glucagon-stimulated adenylate cyclase activity up to a maximum at 50 mM-benzyl alcohol. Further increases in benzyl alcohol concentration inhibited the activity. The fluoride-stimulated adenylate cyclase activity was similarly affected except for an inhibition of activity occurring at low benzyl alcohol concentrations (approx. 10 mM. 2. The fluoride-stimulated adenylate cyclase activity of a solubilized enzyme preparation was unaffected by any of the benzyl alcohol concentrations tested. 3. Increases in 3-phenylpropan-1-ol and 5-phenylpentan-1-ol concentrations progressively activated both the fluoride- and glucagon-stimulated adenylate cyclase activities up to a maximum, above which further increases in alcohol concentration inhibited the activities. 4. The 'break' points in Arrhenius plots of glucagon-stimulated adenylate cyclase activity in native plasma membranes, and in plasma membranes fused with synthetic dimyristoyl phosphatidylcholine so as to constitute 60% of the total lipid pool, were decreased by approx. 6 degrees C by addition of 40 mM-benzyl alcohol. This was accompanied by a fall in the associated activation energies. 6. Arrhenius plots of fluoride-...Continue Reading

Citations

Nov 1, 1981·Toxicology and Applied Pharmacology·P D WilliamsC R Ross
Jul 16, 1984·European Journal of Biochemistry·Z Kiss, V A Tkachuk
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D Schachter
Jul 1, 1985·The Proceedings of the Nutrition Society·M D Houslay
Feb 12, 1980·Biochemical and Biophysical Research Communications·P A Hyslop, D A York
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Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D AlvaroL Capocaccia
Oct 15, 1980·Archives of Biochemistry and Biophysics·P L Lad, W T Shier
Apr 15, 2008·Chemistry and Physics of Lipids·Jong-Hwa LeeIl Yun
Aug 1, 1990·Journal of Applied Toxicology : JAT·P Muriel, M Mourelle
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SchullerA M Municio
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