PMID: 16520530Mar 8, 2006Paper

The activity of matrix metalloproteinases (MMPS) and tissue inhibitors of metalloproteinases (TIMPs) in mammary tumors of dogs and rats

The Journal of Veterinary Medical Science
Kouji KawaiHiroyuki Nakayama

Abstract

We conducted zymography for detecting the activity of matrix metalloproteinases (MMPs) and reverse zymography for the activity of tissue inhibitors of metalloproteinases (TIMPs) in canine spontaneous and rat 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumor tissues. The activities of MMPs of canine mammary tumors were quite higher than those of the rat chemically induced tumors. The activities of MMPs were significantly higher in malignant tissues than in benign ones of canine tumors, whereas the activity of only MMP-2 was higher in both benign and malignant rat tumors compared to normal tissues. There were no differences of MMPs activities between benign and malignant rat tumors. The results of reverse zymography indicated that the activities of TIMP-1, -2 and -3 were strikingly higher in rat tumors than in canine tumors. The activities were higher in malignant tissues than in benign ones of dogs, and higher in tumor tissues than in normal mammary tissues of rats. The results of film in situ zymography for tissue localization of gelatinolytic activity showed that the digested area was more extended in malignant tumors than in benign ones of dogs. However, the area was similarly extended in both benign and malignant ...Continue Reading

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Citations

Jul 6, 2011·BMC Veterinary Research·Luca AresuMauro Dacasto
Sep 1, 2010·Journal of Toxicologic Pathology·Ayako SayamaHiroyuki Nakayama
Apr 27, 2012·American Journal of Veterinary Research·Andreia A SantosAugusto J F de Matos
Nov 18, 2011·Journal of the American Veterinary Medical Association·John E Bauer
Mar 17, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yasuko Hasegawa-Baba, Kunio Doi
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·O LampA Einspanier
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Jan 29, 2011·The Veterinary Journal·Andreia SantosAugusto de Matos
May 3, 2016·Veterinary and Comparative Oncology·L H Pulz, R F Strefezzi
Sep 7, 2017·Journal of Veterinary Internal Medicine·M T MandaraG Guelfi
Mar 24, 2007·International Journal of Clinical Oncology·Motoshi MiyagiKazuo Shirouzu
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Enni Markkanen

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