PMID: 6403648Mar 1, 1983Paper

The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3

The Journal of Experimental Medicine
E C LattimeO Stutman

Abstract

Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa-5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.

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Citations

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·G BoltzA Gangl
Jan 1, 1986·Immunologic Research·E C LattimeO Stutman
Jan 1, 1991·Immunologic Research·E C Lattime, O Stutman
Feb 1, 1989·Veterinary Immunology and Immunopathology·C G Cook, G A Splitter
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W GoodmanS G Shinpock
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·A H SchinkelP Borst
Jan 1, 1992·Immunopharmacology and Immunotoxicology·T M PetroY K Fung
Jan 1, 1987·Annales De L'Institut Pasteur. Immunology·M F LucianiP Golstein
Oct 1, 1983·Scandinavian Journal of Immunology·K O GrönvikP Stern
Aug 1, 1988·Cellular Immunology·M P ChangT Makinodan
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·J A LustV Kumar
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·E C LattimeO Stutman
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·E C Lattime, O Stutman
Feb 1, 1989·Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine·I Pajus, G A Boffa

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