PMID: 9552713Jan 1, 1997Paper

The activity of rifabutin against Mycobacterium leprae in armadillos

International Journal of Antimicrobial Agents
A M Dhople, S L Williams

Abstract

The activity of rifabutin (LM 427) against Mycobacterium leprae was evaluated in armadillos inoculated earlier with human-derived M. leprae. Rifabutin was administered daily at a dose of 6 mg/kg body weight/day. The effect of rifabutin on M. leprae harvested from armadillos was determined by measuring the intracellular levels of ATP (an indicator of metabolic activity) of M. leprae and also their ability to multiply in the mouse footpads and in vitro in DH medium. Within 2 weeks of initiating the treatment, ATP levels declined to 21% of the original (pre-treatment level) and these M. leprae failed to multiply in the footpads of mice as well as in the in vitro culture system. This suggests that rifabutin was able to kill all M. leprae within 2 weeks. After 8 weeks the treatment was terminated and results showed that M. leprae from the treated armadillos remained non-viable in the mouse footpad system as well as in the in vitro system, indicating bactericidal action of rifabutin. The results suggest that rifabutin can be a substitute for rifampin in the leprosy multi-drug therapy regimen.

References

Jan 1, 1991·Microbiology and Immunology·A M Dhople, L C Lamoureux
Jan 1, 1991·Microbiology and Immunology·A M Dhople, L C Lamoureux
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·M H SkinnerT F Blaschke
Mar 1, 1988·Annales De L'Institut Pasteur. Microbiology·A M DhopleL J Osborne
Dec 1, 1985·European Journal of Clinical Microbiology·B BeckersA Lammers
Nov 5, 1983·Lancet·R C Hastings, R R Jacobson
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Jul 1, 1983·Reviews of Infectious Diseases·W E Bullock
Apr 1, 1995·The Journal of Antimicrobial Chemotherapy·A M Dhople, M A Ibanez

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Citations

Jun 1, 2012·Case Reports in Medicine·Charles M KwobahAbraham M Siika
Mar 25, 2016·The Journal of Antimicrobial Chemotherapy·Yoann CrabolOlivier Lortholary

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