The activity of sodium cromoglycate analogues in human lung in vitro: a comparison with rat passive cutaneous anaphylaxis and clinical efficacy

British Journal of Pharmacology
M K Church, C F Gradidge


1 Eleven analogues of sodium cromoglycate have been tested for their ability to suppress histamine release induced by anti-IgE from passively sensitized human lung fragments in vitro. 2 With the exception of WY 16922, which released histamine at high concentrations, all inhibited histamine release in a linear dose-related manner. 3 The analogues were 30 to 1500 times more potent than sodium cromoglycate. However, their regression slopes of activity upon log-concentration were only one-third as steep as that for sodium cromoglycate, indicating a possible difference in their mechanism of action. 4 In comparison with sodium cromoglycate, the analogues were more potent in human lung than in rat passive cutaneous anaphylaxis (PCA); there was no quantitative correlation between potencies in the two tests. 5 The human lung model is not predictive of anti-asthmatic activity in man as the six analogues tested clinically are less effective than sodium cromoglycate. 6 These results throw doubt on the use of models of mast cell degranulation in the search for anti-allergic drugs and, possibly, on the relative importance of mast cell degranulation in the pathogenesis of asthma.


May 24, 1975·Lancet·J F BatchelorJ E Tateson
Jan 1, 1977·International Archives of Allergy and Applied Immunology·J El-Azab, P B Stewart
Nov 9, 1978·Life Sciences·M K Church, C F Gradidge
Jan 13, 1979·British Medical Journal·H R GribbinA E Tattersfield
May 1, 1978·Clinical Allergy·A MuittariT Veneskoski
Sep 1, 1976·Clinical Allergy·R PauwelsM Van der Straeten
Jan 3, 1977·European Journal of Clinical Pharmacology·H Poppius, B Stenius
Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Oct 18, 1974·Nature·B J BroughtonD R Maxwell
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J FullartonC Vardey
Oct 26, 1973·The Medical Letter on Drugs and Therapeutics
Dec 1, 1970·Acta Allergologica·B Elgefors, H Formgren
Aug 1, 1980·British Journal of Pharmacology·M K Church, C F Gradidge


Dec 1, 1982·Agents and Actions·M de Lourdes Arruzazabala, R G Alvarez
Dec 17, 1981·European Journal of Pharmacology·A A CouttsG Burnstock
Jan 1, 1987·International Journal of Immunopharmacology·L J RobichaudR L Adolphson
Jul 2, 2015·European Journal of Pharmacology·Tao ZhangJohn Jarlath Walsh
Aug 1, 1980·British Journal of Pharmacology·M K Church, C F Gradidge
Oct 1, 1981·Acta Pharmacologica Et Toxicologica·C G Persson, G Kjellin
Apr 1, 1988·The Journal of Pharmacy and Pharmacology·A Subissi, M Del Monte
Jan 1, 1985·Contact Dermatitis·H MeffertW Günther

Related Concepts

Histamine Release
Immunoglobulin E
Passive Cutaneous Anaphylaxis
Rats, Laboratory
In Vitro [Publication Type]

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