The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice

Journal of Psychopharmacology
Kathryn S SaadatA Richard Green

Abstract

When mice are exposed to harmless objects such as marbles in their cage they bury them, a behaviour sometimes known as defensive burying. We investigated the effect of an acute dose of MDMA (èecstasy') and other psychoactive drugs on marble burying and also examined the effect of a prior neurotoxic dose of MDMA or p-chloroamphetamine (PCA) on burying. Acute administration of MDMA produced dose-dependent inhibition of marble burying (EC50: 7.6 micro mol/kg). Other drugs that enhance monoamine function also produced dose-dependent inhibition: methamphetamine PCA paroxetine MDMA GBR 12909 methylphenidate. None of these drugs altered locomotor activity at a dose that inhibited burying. A prior neurotoxic dose of MDMA, which decreased striatal dopamine content by 60%, but left striatal 5-HT content unaltered, did not alter spontaneous marble burying 18 or 40 days later. However, a neurotoxic dose of PCA which decreased striatal dopamine by 60% and striatal 5-HT by 70% attenuated marble burying 28 days later. Overall, these data suggest that MDMA, primarily by acutely increasing 5-HT function, acts like several anxiolytic drugs in this behavioural model. Long-term loss of cerebral 5-HT content also produced a similar effect. Since th...Continue Reading

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Citations

Jan 27, 2015·Physiology & Behavior·Marta Rodríguez-AriasJosé Miñarro
Jul 1, 2008·European Journal of Pharmacology·M Daza-LosadaJ Miñarro
Jan 1, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Daza-LosadaJ Miñarro
Jul 12, 2012·Addiction Biology·Hiroki IshiguroTadao Arinami

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