The acute and residual effects of escalating, analgesic-range doses of ketamine on driving performance: A simulator study

Progress in Neuro-psychopharmacology & Biological Psychiatry
Amie HayleyYahya Shehabi

Abstract

Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixed, stepwise increasing sub-anaesthetic doses of intravenous (IV) ketamine solution [(i) 8 mg/h IV infusion plus 30 mg bolus, (ii) 12 mg/h IV infusion and (iii) 20 mg/h infusion]. Whole blood ketamine and norketamine concentrations were determined at each treatment step and at 2 h post-infusion. Driving performance was assessed at baseline, at each treatment step and at 2 h post-treatment using a validated computerised driving simulator. Standard Deviation of Lateral Position (SDLP) and Steering Variability (SV) were assessed. Linear Fixed Effect Modelling indicated a main effect for time (dose) for SDLP (F[4,72] = 33.22, p < 0.0001) and SV (F[4,72] = 4.65, p < 0.002). Post-hoc analyses revealed significant differences from baseline at each treatment step for SDLP (all p < 0.001), and for 12 mg/h treatment step for SV (p = 0.049). Post-treatment driving performance returned to baseline levels. Weak positive linear a...Continue Reading

References

Jan 1, 1981·British Journal of Anaesthesia·J A Clements, W S Nimmo
Jan 14, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J W NewcomerJ W Olney
Jun 4, 1999·Journal of Pain and Symptom Management·M C EnarsonM A Woodroffe
May 1, 2002·Clinical Neuropharmacology·Joëlle MicallefOlivier Blin
Oct 31, 2002·Human Psychopharmacology·Carolyn Brice, Andrew Smith
Nov 23, 2006·Experimental and Clinical Psychopharmacology·Michelle R LofwallMiriam Z Mintzer
May 15, 2009·International Journal of Environmental Research and Public Health·Joris C Verster, Monique A J Mets
Apr 13, 2010·Accident; Analysis and Prevention·Michael G LennéJennifer R Redman
Jun 15, 2011·Forensic Science International : Synergy·Mark ChuOlaf H Drummer
Nov 29, 2011·Forensic Science International : Synergy·Vigdis VindenesJørg Mørland
Apr 12, 2013·CNS Neuroscience & Therapeutics·Georges Mion, Thierry Villevieille
Apr 30, 2013·Journal of Forensic and Legal Medicine·Hilary J BurchMichael Scott-Ham
Dec 23, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Julie Jouguelet-LacosteJacques E Chelly
Apr 18, 2015·Anesthesia, Essays and Researches·Madhuri S KurdiRadhika S Deva
May 20, 2015·Forensic Science International : Synergy·R GiorgettiF Schifano
Jun 19, 2015·Current Drug Abuse Reviews·Amie C HayleyLuke A Downey
Nov 4, 2015·Accident; Analysis and Prevention·Luke A DowneyCon Stough
Mar 28, 2017·Accident; Analysis and Prevention·Christopher IrwinDanielle McCartney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.