The acute antihypertensive effect of ketanserin increases with age

Journal of Cardiovascular Pharmacology
J De CréeJ Symoens


The relationship between the acute blood pressure lowering effect of ketanserin with age was investigated in 57 patients ranging from 25 to 90 years (mean 61 years). There was a highly significant correlation between the degree of reduction of systolic and diastolic blood pressure and age, independent of the starting blood pressure. The fact that the acute blood pressure-lowering effect of ketanserin increases with age may suggest a role for serotonin in blood pressure regulation, particularly in elderly patients.


Jan 1, 1993·European Journal of Clinical Pharmacology·G GleerupK Winther
Jan 1, 1987·European Journal of Clinical Pharmacology·B PerssonT Hedner
Jan 16, 2002·European Journal of Pharmacology·R D BuñagJennifer R Mellick
Jan 1, 1990·British Journal of Clinical Pharmacology·P A van ZwietenP van Brummelen
Nov 1, 1992·Journal of Internal Medicine·M BurnierH R Brunner
Jul 17, 1998·Aging : Clinical and Experimental Research·R D Buñag, L W Davidow
Jan 1, 1990·Cardiovascular Drugs and Therapy·J C van Oene
Aug 1, 1994·Aging : Clinical and Experimental Research·L W DavidowR D Buñag
Mar 1, 1991·The American Journal of Medicine·K O'MalleyE T O'Brien
Mar 1, 1986·Journal of Autonomic Pharmacology·J R Docherty
Mar 1, 1996·Journal of Cardiovascular Pharmacology·R A GeerlingR L Marquet

Related Concepts

Antihypertensive Agents
Diastolic Blood Pressure
Hypertensive Disease
Intravenous Injections

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.