The acute effect of smoking in healthy and asthmatic smokers

European Journal of Clinical Investigation
A I PapaioannouKonstantinos Kostikas

Abstract

Acute exposure to cigarette smoke is related to airway and systemic inflammation and oxidative stress. Little is known about the acute effect of cigarette smoking in smoking asthmatics. The aim of this study was to evaluate the acute effect of smoking in airway and systemic inflammation and oxidative stress in normal smokers and patients with properly treated well-controlled persistent asthma. Ten normal smokers and 10 smokers with moderate persistent asthma controlled with LABA and ICS were recruited. Subjects refrained from smoking for at least 12 h prior to their inclusion. We compared the effects of smoking of two cigarettes on airway obstruction, airway inflammation and oxidative stress [by measuring fraction of exhaled nitric oxide (FeNO), plus pH and 8-isoprostane in exhaled breath condensate (EBC)] before and 30, 90 and 180 min after smoking. Furthermore, we evaluated systemic oxidative stress, C-reactive protein (CRP) and serum amyloid A (SAA) and urine leukotriene E(4) (LTE(4)) before and 180 min after smoking. No differences were observed in EBC pH and 8-isoprostane, FeNO and systemic oxidative stress between the groups at baseline. In asthmatics, EBC pH decreased 30 min and EBC 8-isoprostane increased 90 min after s...Continue Reading

References

Sep 1, 1977·Archives of Environmental Health·B HolmaJ M Andersen
Jul 1, 1980·British Journal of Diseases of the Chest·T W HigenbottamT J Clark
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 15, 1994·Lancet·S A KharitonovP J Barnes
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Oct 22, 1998·The New England Journal of Medicine·P LangeG Jensen
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·F L RicciardoloP Geppetti
Jun 1, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M D AlthuisD Prybylski
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·P MontuschiP J Barnes
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Konstantinos KostikasStelios Loukides
May 13, 2003·Chest·Robert A SilvermanCarlos A Camargo
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Rekha ChaudhuriNeil C Thomson
Jul 30, 2004·Thorax·H van der VaartN H T ten Hacken
Oct 7, 2004·Respiration; International Review of Thoracic Diseases·Ildikó HorváthPeter J Barnes
Nov 2, 2004·The European Respiratory Journal·N C ThomsonE Livingston
Mar 3, 2005·Respiratory Research·Hester van der VaartNick H T ten Hacken
Mar 24, 2005·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Catherine Lemiere, L-P Boulet
Nov 3, 2005·The European Respiratory Journal·B W M WillemseW Timens
Apr 29, 2006·American Journal of Respiratory and Critical Care Medicine·Rekha ChaudhuriNeil C Thomson
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·Zoe D DaniilKonstantinos I Gourgoulianis
Dec 16, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Michelle GillRaed A Dweik
Oct 24, 2007·Chest·Konstantinos KostikasKonstantinos I Gourgoulianis
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A Katsabeki-KatsafliK I Gourgoulianis

❮ Previous
Next ❯

Citations

Sep 26, 2012·International Archives of Occupational and Environmental Health·Anita Ljubičić ĆalušićJelena Macan
Nov 15, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Shunsuke TaitoHironobu Hamada
May 24, 2011·Respiratory Research·Andriana I PapaioannouKonstantinos Kostikas
Nov 6, 2013·Journal of Chromatographic Science·Masha PitiranggonBeizhan Yan
Dec 7, 2010·Experimental Lung Research·Anita Ljubičić CalušićJelena Macan
Jun 25, 2015·TheScientificWorldJournal·Efstathia M KonstantinidiPanagiotis K Behrakis
Dec 12, 2012·Respiratory Medicine·Konstantinos KostikasYiannis Koutedakis
Sep 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J Ghio
Sep 22, 2018·PloS One·Rosalia EmmaUNKNOWN U-BIOPRED Study Group
Mar 9, 2011·Journal of Breath Research·Shamsah Kazani, Elliot Israel
Apr 24, 2012·Journal of Breath Research·Philippe Rosias
Mar 13, 2019·Journal of Breath Research·Anneli Ahovuo-SalorantaLauri Lehtimäki
Apr 3, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Serafeim-Chrysovalantis KotoulasDespoina Papakosta
Jun 3, 2020·International Journal of Molecular Sciences·Yara ShomanIrina Guseva Canu
Oct 10, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Deniz CelikUnal Erkorkmaz
Sep 26, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andreas S LappasPanagiotis K Behrakis
Jul 21, 2020·Minerva pediatrica·Maria Di CiccoPasquale Comberiati
May 1, 2021·Nutrition Research Reviews·Emanuela AstoriIsabella Dalle-Donne
Aug 28, 2021·Journal of Personalized Medicine·Serafeim-Chrysovalantis KotoulasAthanasia Pataka
Dec 10, 2020·Respiration; International Review of Thoracic Diseases·Martin GaisbergerArnulf Hartl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The European Respiratory Journal
Ildikó HorváthATS/ERS Task Force on Exhaled Breath Condensate
American Journal of Respiratory and Critical Care Medicine
Konstantinos KostikasStelios Loukides
American Journal of Respiratory and Critical Care Medicine
John Hunt
© 2022 Meta ULC. All rights reserved