The acute effects of nasal positive pressure ventilation in patients with advanced cystic fibrosis

Chest
J T Granton, S Kesten

Abstract

To evaluate the acute effects of noninvasive positive pressure ventilation (NPPV) in patients with stable chronic respiratory failure secondary to cystic fibrosis. Eight patients (29+/-5 years of age) with severe airflow limitation (mean FEV1, 24+/-3% predicted) and chronic respiratory failure (PaO2=67+/-15 mm Hg and PaCO2=50+/-4 mm Hg) were evaluated. Tidal volume, respiratory rate, minute ventilation, oxygen saturation, and transcutaneous CO2 (TcCO2) measurements were made over a 20-min period before and after the application of NPPV (inspiratory pressure of 10 to 12 cm H2O and expiratory pressure of 4 to 6 cm H2O). NPPV increased saturation from 88+/-2% to 90+/-1% (p<0.05) and decreased TcCO2 from 51+/-3 mm Hg to 50+/-2 mm Hg (p<0.05). Tidal volume increased from 219+/-20 mL to 256+/-37 mL (p=not significant [NS]) and respiratory rate decreased from 24+/-2 to 18+/-1 (p<0.01). Minute ventilation decreased from 5.3+/-0.8 L/min to 4.6+/-0.6 L/min (p=0.08). There was no change in duty cycle (32+/-5% to 34+/-5%, p=NS). In two patients, esophageal pressure measurements were also recorded. There was a decrease in pressure from -21+/-1 cm H2O to -11+/-2 cm H2O and -14+/-1 cm H2O to -7+/-1 cm H2O. In patients with stable, severe cyst...Continue Reading

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References

May 5, 1978·JAMA : the Journal of the American Medical Association·P B Davis, P A di Sant'Agnese
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·D J Meecham JonesJ A Wedzicha
Sep 28, 1995·The New England Journal of Medicine·L BrochardF Lemaire
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·G T Ferguson, M Gilmartin

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Citations

Apr 30, 2005·Journal of Palliative Medicine·W Robinson
Nov 14, 2001·Current Opinion in Pulmonary Medicine·R Hamutcu, M S Woo
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Madiha EllaffiDaniel Dusser
Aug 27, 2014·Clinics in Chest Medicine·Eliot S Katz
Nov 9, 2007·Respiration; International Review of Thoracic Diseases·Brigitte FaurouxAnnick Clément
Apr 14, 2010·Expert Review of Respiratory Medicine·Brigitte Fauroux
Mar 2, 2016·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Maria Cecilia Rodriguez HortalLena Hjelte
Feb 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Catherine J DobbinPeter T P Bye
Oct 20, 2018·Journal of Pediatric Gastroenterology and Nutrition·Bat-El Bar AlumaOri Efrati
Jun 6, 2003·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Paolo PelosiMaurizio Chiaranda

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