The acute impact of ethanol on glucose, insulin, triacylglycerol,and free fatty acid responses and insulin sensitivity in type 2 diabetes

The British Journal of Nutrition
C ChristiansenK Hermansen

Abstract

The aim of the present study was to evaluate the acute effect of ethanol on insulin sensitivity, and glucose, insulin, free fatty acid (FFA), and triacylglycerol responses in ten patients with non-insulin-dependent (type 2) diabetes. In the test study an oral dose of 0.66 g ethanol/kg followed by continuous intravenous infusion of 0.1 g ethanol/kg per h was given to maintain a constant ethanol level in the blood. In the control study identical volumes of oral water and intravenous saline (9 g NaCl/l) were given. After 90 min insulin sensitivity was determined by the hyperinsulinaemic, euglycaemic clamp technique. Ethanol caused no change in blood glucose or insulin concentrations. The FFA level was suppressed by ethanol while the triacylglycerol level was unaffected. The insulin sensitivity was not affected by ethanol. No major acute effect of ethanol on the glycaemic control in fasting type 2 diabetic patients was found in comparison with what is seen in healthy people. The present study, along with the sparse literature, indicates that the ability of ethanol to induce hypoglycaemia is attenuated or absent in diet-treated type 2 diabetes. Furthermore, we found no change in insulin sensitivity. Consequently, the risk of acute e...Continue Reading

References

Mar 1, 1976·Clinical Science and Molecular Medicine·J Yudkin, R D Cohen
Jul 1, 1978·Clinics in Endocrinology and Metabolism·V Marks
Jan 1, 1975·Zeitschrift für Rechtsmedizin. Journal of legal medicine·G Machata
May 1, 1975·Metabolism: Clinical and Experimental·J McMonagle, P Felig
Nov 1, 1991·Metabolism: Clinical and Experimental·L MishraE Mezey
Sep 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·H Connor, V Marks
Apr 1, 1988·The Journal of Clinical Investigation·J J ShelmetG Boden
Aug 1, 1988·The American Journal of the Medical Sciences·J GravesF C Whittier
Jan 1, 1987·Diabetologia·L L NgT D Hockaday
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·H Yki-Järvinen, E A Nikkilä
May 1, 1974·Diabetes·C H Walsh, D J O'Sullivan
Nov 1, 1968·Metabolism: Clinical and Experimental·R A ArkyN Freinkel
Sep 1, 1967·The American Journal of Clinical Nutrition·M Verdy, A Gattereau
Jul 1, 1994·Diabetes/metabolism Reviews·A J ScheenP J Lefèbvre
Feb 1, 1993·The Journal of Clinical Investigation·S Del PratoR A DeFronzo
Jun 1, 1965·Diabetes·N FREINKELA E FOSTER

❮ Previous
Next ❯

Citations

Oct 8, 2004·The British Journal of Nutrition·Marian DalgaardKjeld Hermansen
May 1, 2004·Journal of Medicinal Food·Sun-ju Yi, Byung H Jhun
Feb 2, 2002·Current Atherosclerosis Reports·Henry J Pownall
Jun 18, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A PietraszekK Hermansen
Nov 14, 2007·Metabolism: Clinical and Experimental·Darleen A SandovalStephen N Davis
May 25, 1999·Metabolism: Clinical and Experimental·B M RasmussenK Hermansen
Nov 29, 2005·Pharmacology & Therapeutics·Justin W Ting, W Wayne Lautt
Jun 1, 2012·The American Journal of Clinical Nutrition·Katja A HätönenLiisa M Valsta
Aug 18, 2021·JHEP Reports : Innovation in Hepatology·Mads IsraelsenUNKNOWN MicrobLiver Consortium

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.