The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2.

Nanoscale Research Letters
Linglan MaFashui Hong

Abstract

Although it is known that nano-TiO2or other nanoparticles can induce liver toxicities, the mechanisms and the molecular pathogenesis are still unclear. In this study, nano-anatase TiO2(5 nm) was injected into the abdominal cavity of ICR mice for consecutive 14 days, and the inflammatory responses of liver of mice was investigated. The results showed the obvious titanium accumulation in liver DNA, histopathological changes and hepatocytes apoptosis of mice liver, and the liver function damaged by higher doses nano-anatase TiO2. The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO2can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-κB, macrophage migration inhibitory factor, tumor necrosis factor-α, interleukin-6, interleukin-1β, cross-reaction protein, interleukin-4, and interleukin-10. Our results also implied that the inflammatory responses and liver injury may be involved in nano-anatase TiO2-induced liver toxicity.

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Citations

Jan 1, 2009·Nanoscale Research Letters·Na LiYaning Xie
Oct 21, 2009·Biological Trace Element Research·Yanmei DuanFashui Hong
Mar 23, 2011·Biological Trace Element Research·Jyotisree UnnithanM Samim
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Jan 29, 2013·Nanoscale Research Letters·Xuhong ChangBei Wang
Apr 17, 2013·Particle and Fibre Toxicology·Hongbo ShiJinshun Zhao
Mar 25, 2014·PloS One·Yuguan ZeFashui Hong
Jan 1, 2016·Journal of Agricultural and Food Chemistry·Fashui HongLing Wang
Aug 18, 2012·Journal of Hazardous Materials·Qingqing SunFashui Hong
Sep 13, 2011·Journal of Hazardous Materials·Suxing GuiFashui Hong
Aug 21, 2010·Journal of Hazardous Materials·Yaling CuiFashui Hong
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Yaling CuiFashui Hong
Jan 26, 2012·Journal of Biomedical Materials Research. Part a·Xuezi SangFashui Hong
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Lei ShengFashui Hong
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Jul 7, 2015·Journal of Agricultural and Food Chemistry·Fashui HongJianhao Zhang
Aug 14, 2015·Nanoscale Research Letters·Fashui HongLei Sheng
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Sep 3, 2014·Journal of Hazardous Materials·Xiaohong YuFashui Hong
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Methods Mentioned

BETA
bronchoalveolar lavage
X-ray
Assay
PCR
enzyme linked immunosorbent assay
ELISA

Software Mentioned

Primer Express

Related Concepts

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