The acute phase response of plasma proteins in the polyprotodont marsupial Monodelphis domestica

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
S J RichardsonG Schreiber

Abstract

In eutherians, patterns of plasma protein levels in blood change during the acute phase response to trauma and inflammation. Until now, such an acute phase response has not been characterised in a noneutherian species. Here we describe the acute phase response in a marsupial species, the South American polyprotodont marsupial Monodelphis domestica, after brain surgery or injection of lipopolysaccharide. Several days after brain surgery, transthyretin was not detected in plasma. For 48 hr following injection of lipopolysaccharide, the concentration of haptoglobin in plasma increased, that of transthyretin decreased, and the concentration of albumin in plasma did not change significantly. The American polyprotodont marsupials are probably more closely related to the common ancestor marsupial than the Australian marsupials are. It is most likely that the transthyretin gene was not expressed in the liver of this common ancestor. As the transthyretin gene is expressed in the liver of M. domestica, it seems that as soon as transthyretin is synthesised by the liver, it is under negative acute phase control.

References

Jan 1, 1988·Veterinary Research Communications·P D Eckersall, J G Conner
Dec 1, 1988·Inflammation·F A De JongG Schreiber
Jan 1, 1989·Annals of the New York Academy of Sciences·G SchreiberJ Milland
Oct 1, 1965·The American Journal of Physiology·H E Weimer, D C Benjamin
Nov 15, 1973·Journal of Molecular Biology·U K Laemmli, M Favre
May 1, 1973·Developmental Biology·M B Renfree, C H Tyndale-Biscoe
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·B Weeke
Feb 4, 1969·Biochimica Et Biophysica Acta·W DobryszyckaJ C Kukral
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Woźniak
Dec 15, 1982·European Journal of Biochemistry·P W DicksonG Schreiber
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jan 1, 1993·International Journal of Legal Medicine·A Krüger, K Püschel
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson

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Citations

Feb 5, 2002·General and Comparative Endocrinology·Samantha J RichardsonGerhard Schreiber
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Samantha J Richardson
Sep 4, 2009·The FEBS Journal·Samantha J Richardson
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J Murray, J A Salomon

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