The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling

Free Radical Biology & Medicine
G TapiaL A Videla

Abstract

Recently, we reported that 3,3',5-triiodothyronine (T3) induces the expression of redox-sensitive genes as a nongenomic mechanism of T3 action. In this study, we show that T3 administration to rats (daily doses of 0.1 mg/kg ip for 3 consecutive days) induced a calorigenic response and liver glutathione depletion as an indication of oxidative stress, with higher levels of interleukin (IL)-6 in serum (ELISA) and hepatic STAT3 DNA binding (EMSA), which were maximal at 48-72 h after treatment. Under these conditions, the protein expression of the acute-phase proteins haptoglobin and beta-fibrinogen is significantly augmented, a change that is suppressed by pretreatment with alpha-tocopherol (100 mg/kg ip) or gadolinium chloride (10 mg/kg iv) before T3. It is concluded that T3 administration induces the acute-phase response in rat liver by a redox mechanism triggered at the Kupffer cell level, in association with IL-6 release and activation of the STAT3 cascade, a response that may contribute to reestablishing homeostasis in the liver and extrahepatic tissues exhibiting oxidative stress.

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Citations

Feb 7, 2008·Comparative Hepatology·Maria-Angeles AllerJorge-Luis Arias
Jul 28, 2007·Biological Chemistry·Virginia FernándezLuis A Videla
May 9, 2012·World Journal of Hepatology·Virginia FernándezLuis A Videla
Dec 6, 2011·The Journal of Nutritional Biochemistry·Marcelo MardonesGladys Tapia
Mar 23, 2010·Molecular and Cellular Endocrinology·G TapiaV Fernández
Oct 6, 2015·Free Radical Biology & Medicine·Luis A VidelaNelson Varela
Sep 5, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Juergen BeigelPhilip Hewitt
Jun 15, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S ChattopadhyayG B N Chainy
May 26, 2015·Expert Reviews in Molecular Medicine·Luis A VidelaIván Castillo
Oct 6, 2015·PloS One·Rolando A RebolledoPamela Romanque
Nov 18, 2016·The Journal of Endocrinology·Anne H van der SpekAnita Boelen
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Virginia FernándezLuis A Videla
Oct 31, 2009·World Journal of Hepatology·Luis A Videla
Jun 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fan YangXi-Qin Ding
Sep 25, 2019·Cells·Mónica B Jiménez-CastroCarmen Peralta

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