PMID: 18406315Apr 15, 2008Paper

The acute regulation of mineralocorticoid biosynthesis: scenarios for the StAR system

Trends in Endocrinology and Metabolism : TEM
N Cherradi, A M Capponi

Abstract

The zona glomerulosa cell of the adrenal cortex produces mineralocorticoids in response to physiological stimuli (angiotensin II and extracellular K(+)) activating the Ca(2+) messenger system. The mechanisms underlying the generation of the Ca(2+) signal have been analyzed extensively and recent developments have contributed to bridging the gap between intracellular signals and activation of the biological function. This article summarizes the current knowledge on the intracellular targets of the Ca(2+) messenger, obtained mainly in bovine glomerulosa cells. Ca(2+) appears to exert a dual effect, both at the intramitochondrial level and at the nuclear level, where it activates steroidogenic acute regulatory protein (StAR) gene transcription.

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Citations

Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Alessandro M Capponi
May 6, 2003·Archives of Biochemistry and Biophysics·Aida UribeFederico Martínez
May 3, 2011·Cell Metabolism·Andreas WiederkehrClaes B Wollheim
Sep 7, 2016·Molecular and Cellular Endocrinology·Mabrouka Doghman-Bouguerra, Enzo Lalli
Sep 27, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·A SpätG Szabadkai
Oct 29, 2011·Toxicology and Applied Pharmacology·Rabia LatifMuhammad Aslam

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