The acute transient polymorphic psychosis: a biochemical subtype of the cycloid psychosis

Acta Neuropsychiatrica
L PepplinkhuizenD Fekkes


The pathogenesis of atypical psychoses, in particularly those characterized by polymorphic psychopathology, is hypothesized to be related to disturbances in amino acid metabolism. In the present study, the role of the amino acid serine was investigated in patients with acute transient polymorphic psychosis. Patients were loaded with serine and with the amino acids glycine and alanine as controls and subsequently evaluated for the development of psychopathological symptoms. In addition, plasma levels of amino acids were measured. In a subgroup of patients suffering from atypical psychoses, this biochemical challenge resulted in the reappearance of psychedelic symptoms in particular. Furthermore, significantly lower plasma concentrations of serine were found. In vitro experiments revealed a disturbance in the one-carbon metabolism. In another group of patients the loading provoked vegetative symptoms and fatigue. Disturbances in amino acid metabolism may be involved in the emergence of certain psychotic disorders.


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Apr 22, 2009·European Archives of Psychiatry and Clinical Neuroscience·A C Castagnini, German E Berrios
Jul 21, 2009·Respiratory Physiology & Neurobiology·C RealP Escourrou
Aug 8, 2018·Nature Communications·Bo WangJure Leskovec
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Aug 1, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A C Castagnini, P Fusar-Poli
Nov 7, 2019·Current Psychiatry Reports·Savita MalhotraSrinivas Balachander

Related Concepts

Psychotic Disorders
Atypical Childhood Psychoses
Subtype (Attribute)
Gene Polymorphism

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