The acute transient polymorphic psychosis: a biochemical subtype of the cycloid psychosis

Acta Neuropsychiatrica
L PepplinkhuizenD Fekkes

Abstract

The pathogenesis of atypical psychoses, in particularly those characterized by polymorphic psychopathology, is hypothesized to be related to disturbances in amino acid metabolism. In the present study, the role of the amino acid serine was investigated in patients with acute transient polymorphic psychosis. Patients were loaded with serine and with the amino acids glycine and alanine as controls and subsequently evaluated for the development of psychopathological symptoms. In addition, plasma levels of amino acids were measured. In a subgroup of patients suffering from atypical psychoses, this biochemical challenge resulted in the reappearance of psychedelic symptoms in particular. Furthermore, significantly lower plasma concentrations of serine were found. In vitro experiments revealed a disturbance in the one-carbon metabolism. In another group of patients the loading provoked vegetative symptoms and fatigue. Disturbances in amino acid metabolism may be involved in the emergence of certain psychotic disorders.

References

Jun 1, 1978·Archives of General Psychiatry·R L SpitzerE Robins
Jan 1, 1988·Pharmacopsychiatry·J BruinvelsD Fekkes
Jan 1, 1986·Progress in Brain Research·A WunderinkJ Bruinvels
Mar 1, 1980·Lancet·L PepplinkhuizenP Moleman
Apr 1, 1952·The Journal of Mental Science·H OSMOND, J R Smythies
Jun 1, 2002·Acta Neuropsychiatrica·F M M A van der HeijdenW M A Verhoeven
Jun 1, 2002·Acta Neuropsychiatrica·A Van DuyseR Rubens

Citations

Apr 22, 2009·European Archives of Psychiatry and Clinical Neuroscience·A C Castagnini, German E Berrios
Jul 21, 2009·Respiratory Physiology & Neurobiology·C RealP Escourrou
Aug 8, 2018·Nature Communications·Bo WangJure Leskovec
Sep 27, 2018·The Journal of Nervous and Mental Disease·A C CastagniniGerman E Berrios
Aug 1, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A C Castagnini, P Fusar-Poli
Nov 7, 2019·Current Psychiatry Reports·Savita MalhotraSrinivas Balachander

Related Concepts

Alanine
Carbon
Glycine
Metabolism
Plasma
Psychotic Disorders
Serine
Atypical Childhood Psychoses
Subtype (Attribute)
Gene Polymorphism

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Prostaglandins, Leukotrienes, and Essential Fatty Acids
D FekkesL Pepplinkhuizen
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
Takaaki AbeSatoshi Kato
Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists
Ravi Philip Rajkumar
© 2021 Meta ULC. All rights reserved