PMID: 36169May 25, 1979

The acyl-CoA desaturases of microsomes from rat liver and the Morris 7777 hepatoma

Biochimica Et Biophysica Acta
R E MortonH P Morris

Abstract

We have investigated the role of the microsomal oxidative desaturase in defining the aberrant phosphoglyceride fatty acid composition of hepatomas. The microsomal delta 9-stearoyl-CoA, delta 6-oleoyl(linolenoyl)-CoA, and delta 5-eicosatrienoyl-CA desaturase activities were studied in control and host liver and in the poorly differentiated Morris 7777 hepatoma. The delta 9-stearoyl-CoA desaturase of the hepatoma was significantly decreased (42%) relative to control liver, yet the hepatoma specific activity was twice that of host liver. Additionally, the specific activity of the delta 9-stearoyl-CoA desaturase of the tumor was found to decrease with increasing tumor weight. Also this desaturase was inactivated by freezing and thawing. The delta 6-oleoyl(linolenoyl)-CoA and delta 5-eicosatrienoyl-CoA desaturases of the hepatoma were 39% and 4% of control, respectively. The electron transport components involved in the desaturase system were reduced, although this did not appear to be rate-limiting. In addition, two competing metabolic reactions which could lower the observed desaturase activities, hydrolysis of the thioester and incorporation of substrate acyl-CoA molecules into glycerides, did not appear to be responsible for the...Continue Reading

References

May 15, 2013·Lipids in Health and Disease·Jinfeng DaiUndurti N Das
May 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D M Perkins, J R Duncan
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D L Wang, R C Reitz
Jan 1, 1983·Nutrition and Cancer·E N Siguel
Jun 4, 2020·Animals : an Open Access Journal From MDPI·Tamil Selvi SundaramAntonella Baldi

Citations

Apr 1, 1972·Archives of Biochemistry and Biophysics·N Oshino, R Sato
May 1, 1974·Lipids·L E ChiappeM E Detomás
Mar 1, 1981·Contact Dermatitis·E W ClarkD S Wilkinson
Jul 1, 2011·The Journal of Antimicrobial Chemotherapy·Christoph WyenGerman Competence Network for HIV/AIDS Coordinators
Jul 19, 2011·Environmental Science & Technology·Jonathan P BenskinJonathan W Martin

Related Concepts

Metabolic Process, Cellular
Pdia3
Desaturase
Acyl CoA Desaturases
Thioester
Cytochrome Reductases
Microsomes
Liver Carcinoma
Electron Transport
Neoplasms

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