PMID: 36169May 25, 1979

The acyl-CoA desaturases of microsomes from rat liver and the Morris 7777 hepatoma

Biochimica Et Biophysica Acta
R E MortonH P Morris


We have investigated the role of the microsomal oxidative desaturase in defining the aberrant phosphoglyceride fatty acid composition of hepatomas. The microsomal delta 9-stearoyl-CoA, delta 6-oleoyl(linolenoyl)-CoA, and delta 5-eicosatrienoyl-CA desaturase activities were studied in control and host liver and in the poorly differentiated Morris 7777 hepatoma. The delta 9-stearoyl-CoA desaturase of the hepatoma was significantly decreased (42%) relative to control liver, yet the hepatoma specific activity was twice that of host liver. Additionally, the specific activity of the delta 9-stearoyl-CoA desaturase of the tumor was found to decrease with increasing tumor weight. Also this desaturase was inactivated by freezing and thawing. The delta 6-oleoyl(linolenoyl)-CoA and delta 5-eicosatrienoyl-CoA desaturases of the hepatoma were 39% and 4% of control, respectively. The electron transport components involved in the desaturase system were reduced, although this did not appear to be rate-limiting. In addition, two competing metabolic reactions which could lower the observed desaturase activities, hydrolysis of the thioester and incorporation of substrate acyl-CoA molecules into glycerides, did not appear to be responsible for the...Continue Reading


May 15, 2013·Lipids in Health and Disease·Jinfeng DaiUndurti N Das
May 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D M Perkins, J R Duncan
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D L Wang, R C Reitz
Jan 1, 1983·Nutrition and Cancer·E N Siguel
Jun 4, 2020·Animals : an Open Access Journal From MDPI·Tamil Selvi SundaramAntonella Baldi


Apr 1, 1972·Archives of Biochemistry and Biophysics·N Oshino, R Sato
May 1, 1974·Lipids·L E ChiappeM E Detomás
Mar 1, 1981·Contact Dermatitis·E W ClarkD S Wilkinson
Jul 1, 2011·The Journal of Antimicrobial Chemotherapy·Christoph WyenGerman Competence Network for HIV/AIDS Coordinators
Jul 19, 2011·Environmental Science & Technology·Jonathan P BenskinJonathan W Martin

Related Concepts

Metabolic Process, Cellular
Acyl CoA Desaturases
Cytochrome Reductases
Liver Carcinoma
Electron Transport

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.