PMID: 4343563Jun 1, 1972

The adaptive behaviour of isoenzyme forms of rat liver alanine aminotransferases during development

The Biochemical Journal
K Snell, D G Walker


1. The activities of the mitochondrial and cytosol isoenzyme forms of l-alanine-glyoxylate and l-alanine-2-oxoglutarate aminotransferases were determined in rat liver during foetal and neonatal development. 2. The mitochondrial glyoxylate aminotransferase activity begins to develop in late-foetal liver, increases rapidly at birth to a peak during suckling and then decreases at weaning to the adult value. 3. The cytosol glyoxylate aminotransferase and the mitochondrial and cytosol 2-oxoglutarate aminotransferase activities first appear prenatally, increase further after birth and then rise to the adult values during weaning. 4. In foetal liver the mitochondrial glyoxylate aminotransferase and the cytosol 2-oxoglutarate aminotransferase activities are increased after injection in utero of glucagon, dibutyryl cyclic AMP (6-N,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate) or thyroxine. The cytosol glyoxylate aminotransferase and the mitochondrial 2-oxoglutarate aminotransferase activities are increased after injection in utero of cortisol or thyroxine. 5. After birth the further normal increases in the mitochondrial and cytosol 2-oxoglutarate aminotransferase activities can be hastened by cortisol injection, whereas the increa...Continue Reading


Oct 1, 1982·Archives internationales de physiologie et de biochimie·L ArolaM Alemany
Jan 14, 1978·Diabetologia·K Snell, D G Walker
May 1, 1979·Journal of Neurochemistry·J OrlickýH Hager
Jan 1, 1984·Journal of Inherited Metabolic Disease·R Matalon, K Michals

Related Concepts

Cyclic AMP, (R)-Isomer
Age Factors
SGPT - Glutamate pyruvate transaminase
Fetal Structures
Mitochondria, Liver

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