The adaptive filter of the yeast galactose pathway

Journal of Theoretical Biology
Serge SmidtasFrançois Képès

Abstract

In the yeast Saccharomyces cerevisiae, the interplay between galactose, Gal3p, Gal80p and Gal4p determines the transcriptional status of the genes required for galactose utilization. After an increase in galactose concentration, galactose molecules bind onto Gal3p. This event leads via Gal80p to the activation of Gal4p, which then induces GAL3 and GAL80 gene transcription. Here we propose a qualitative dynamical model, whereby these molecular interaction events represent the first two stages of a functional feedback loop that closes with the capture of activated Gal4p by newly synthesized Gal3p and Gal80p, decreasing transcriptional activation and creating again the protein complex that can bind incoming galactose molecules. Based on the differential time-scales of faster protein interactions versus slower biosynthetic steps, this feedback loop functions as a derivative filter where galactose is the input step signal, and released Gal4p is the output derivative signal. One advantage of such a derivative filter is that GAL genes are expressed in proportion to cellular requirements. Furthermore, this filter adaptively protects the cellular receptors from saturation by galactose, allowing cells to remain sensitive to variations in...Continue Reading

References

Nov 1, 1992·Molecular and Cellular Biology·M R Parthun, J A Jaehning
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I SadowskiM Ptashne
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Yano, T Fukasawa
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L BardwellJ Thorner
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PlattR J Reece
May 11, 2000·Molecular and Cellular Biology·J R RohdeI Sadowski
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·D A Lauffenburger
Jun 19, 2001·The EMBO Journal·S R Biggar, G R Crabtree
Aug 4, 2001·Genes & Development·S R Bhaumik, M R Green
Mar 26, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Hidde de Jong
Apr 23, 2002·Nature Genetics·Shai S Shen-OrrUri Alon
Jun 22, 2002·Journal of Theoretical Biology·Mineo MorohashiHiroaki Kitano
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gang Peng, James E Hopper
Apr 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Esti Yeger-LotemHanah Margalit
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Subhayu BasuRon Weiss
Sep 15, 2004·Journal of Theoretical Biology·K Sriram, M S Gopinathan
Nov 28, 2006·Comptes rendus biologies·Serge SmidtasFrançois Képès

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Citations

Dec 4, 2012·Systems and Synthetic Biology·Vishwesh V KulkarniMarc Riedel
Feb 4, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Carlo CosentinoFrancesco Amato
Mar 5, 2010·BMC Bioinformatics·Vishwesh V KulkarniGanesh A Viswanathan
Oct 20, 2010·International Journal of Molecular Sciences·Ildefonso Martínez de la Fuente
Nov 28, 2006·Comptes rendus biologies·Serge SmidtasFrançois Képès

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