The Adaptive Remodeling of Stem Cell Niche in Stimulated Bone Marrow Counteracts the Leukemic Niche

Stem Cells
Seon-Yeong JeongIl-Hoan Oh

Abstract

Accumulating studies have shown the cellular nature of hematopoietic stem cell (HSC) niche in bone marrow (BM) and their degenerative changes under leukemic conditions. However, the dynamic adaptation of niche cells to changes in physiological stimulatory signals remains largely uncharacterized. Here, we have established a niche stimulation model induced by 5-fluorouracil. This model reveals a rapid and reversible conversion of mesenchymal cells into niche-like stromal cells, which exhibit a platelet-derived growth factor receptor-alpha+ /leptin receptor+ (PL) phenotype. These cells selectively induce the niche signaling molecule, Jagged-1, but not CXCL12, to initiate a stimulation-induced regeneration of HSCs in a Jagged-1 dependent manner. Conversion of mesenchymal cells into niche-like cells occurred independently of mitotic activation. The conversion was accompanied by the acquisition of primitive mesenchymal cell characteristics, including the rapid induction of stage specific embryonic antigen-3 and the acquisition of clonogenic potential. The stimulation-induced remodeling of the BM niche resulted in a positive stimulatory effect on the regeneration of normal HSC, but exerted inhibitory effects on leukemic cells, leading...Continue Reading

References

Oct 24, 2003·Nature·L M CalviD T Scadden
Jun 2, 2005·The Journal of Experimental Medicine·Sebastian StierDavid T Scadden
Mar 3, 2007·Annals of the New York Academy of Sciences·Fumio Arai, Toshio Suda
Oct 10, 2007·Experimental Hematology·Yoshihiko NakamuraKiyoshi Ando
Oct 24, 2007·Nature Biotechnology·Fumihiko IshikawaLeonard D Shultz
Feb 8, 2008·Nature·Simón Méndez-FerrerPaul S Frenette
May 6, 2008·Blood·Shane R Mayack, Amy J Wagers
Feb 13, 2009·Nature·Marieke A G EssersAndreas Trumpp
Feb 26, 2010·Nature Reviews. Immunology·Andreas TrumppAnne Wilson
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasumasa KurodaMari Dezawa
May 18, 2010·Current Opinion in Hematology·Nadia Carlesso, Angelo A Cardoso
May 28, 2010·Journal of Cellular Biochemistry·Brahmananda R ChittetiMelissa A Kacena
Jun 3, 2010·Stem Cells·Il-Hoan Oh, Kyung-Rim Kwon
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette
Mar 20, 2013·Experimental Hematology·Xiaomiao Li, William B Slayton
Jan 11, 2014·British Journal of Haematology·Yoko Tabe, Marina Konopleva
Jan 17, 2014·Nature·Sean J Morrison, David T Scadden
Aug 8, 2014·Nature Medicine·Avital Mendelson, Paul S Frenette

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Citations

Sep 12, 2018·Stem Cells·Julie R Beegle
Apr 30, 2019·Current Opinion in Hematology·Il-Hoan OhJin-A Kim
May 10, 2019·Current Osteoporosis Reports·Daniel W Youngstrom, Kurt D Hankenson
Jul 30, 2020·Experimental & Molecular Medicine·Seon-Yeong JeongIl-Hoan Oh
Nov 12, 2018·Biochemical Pharmacology·François M ValletteDominique Heymann

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