Nov 16, 2019

The added diagnostic value of complementary gadoxetic acid-enhanced MRI to 18 F-DOPA-PET/CT for liver staging in medullary thyroid carcinoma

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Daniel Puhr-WesterheidePhilipp M Kazmierczak


A high proportion of patients with advanced stages of medullary thyroid carcinoma (MTC) present with liver metastasis metastases. The aim of our study was to investigate the added diagnostic value of complementary gadoxetic acid-enhanced MRI to 18F-DOPA-PET/CT for liver staging in MTC. Thirty-six patients (14 female, median age 55 years) with histologically confirmed MTC undergoing gadoxetic acid-enhanced liver MRI within 1 month of matching contrast-enhanced 18F-DOPA-PET/CT between 2010 and 2016 were selected for this IRB-approved retrospective study. 18F-DOPA-PET/CT and multiparametric MRI data sets were read consecutively and liver lesions were categorised on a 5-point Likert scale (1-definitely benign; 2-probably benign; 3-intermediate risk for metastasis; 4-probably metastasis; 5-definitely metastasis). It was noted if gadoxetic acid-enhanced MRI detected additional, 18F-DOPA-PET/CT-occult metastases (category 5) or if gadoxetic acid-enhanced MRI allowed for a definite classification (categories 1 and 5) of lesions for which 18F-DOPA-PET/CT remained inconclusive (categories 2-4). Follow-up PET/CT and MRI examinations were used as a reference standard. A total of 207 liver lesions (18F-DOPA-PET/CT 149, MRI 207; 152 metastas...Continue Reading

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Mentioned in this Paper

Likert Scale
Magnetic Resonance Imaging (MRI) of Liver
Magnetic Resonance Imaging
Procedures on Liver
PET/CT scan
Secondary Malignant Neoplasm of Liver
Gadoxetic acid

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