The Added Prognostic Value of Preoperative Dynamic Contrast-Enhanced MRI Histogram Analysis in Patients with Glioblastoma: Analysis of Overall and Progression-Free Survival.

AJNR. American Journal of Neuroradiology
Y S ChoiS S Ahn

Abstract

The prognostic value of dynamic contrast-enhanced MR imaging in patients with glioblastoma is controversial. We investigated the added prognostic value of dynamic contrast-enhanced MR imaging to clinical parameters and molecular biomarkers in patients with glioblastoma by using histogram analysis. This retrospective study consisted of 61 patients who underwent preoperative dynamic contrast-enhanced MR imaging for glioblastoma. The histogram parameters of dynamic contrast-enhanced MR imaging, including volume transfer constant, extravascular extracellular volume fraction, and plasma volume fraction, were calculated from entire enhancing tumors. Univariate analyses for overall survival and progression-free survival were performed with preoperative clinical and dynamic contrast-enhanced MR imaging parameters and postoperative molecular biomarkers. Multivariate Cox regression was performed to build pre- and postoperative models for overall survival and progression-free survival. The performance of models was assessed by calculating the Harrell concordance index. In univariate analysis, patients with higher volume transfer constant and extravascular extracellular volume fraction values showed worse overall survival and progression-f...Continue Reading

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Citations

Sep 22, 2018·NMR in Biomedicine·Elies Fuster-GarciaJuan M García-Gómez
Jan 16, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jana IvanidzeGloria C Chiang
Jun 23, 2018·Current Treatment Options in Oncology·K Ina Ly, Elizabeth R Gerstner
Nov 18, 2020·Pharmaceutics·Huilong Luo, Eric V Shusta
Apr 4, 2021·Cancers·Antonella CastellanoGiuseppe Minniti
Aug 30, 2020·Computers in Biology and Medicine·Leonardo F MachadoLuiz O Murta Junior

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