The Addition of Adjuvant Chemotherapy to Radiation in Early-Stage High-Risk Endometrial Cancer: Survival Outcomes and Patterns of Care

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Dustin BootheDavid K Gaffney

Abstract

Early-stage high-risk endometrial cancer (HREC) treated with adjuvant radiotherapy (aRT) alone has been associated with an increased risk of distant relapse. The addition of chemotherapy to radiotherapy (aCRT) may benefit overall survival (OS). We investigated the patterns-of-care and OS benefit of aCRT in HREC by analyzing a large national registry. Our query was limited to patients with the International Federation of Gynecology and Obstetrics stage IB and II HREC with either papillary serous, clear cell, or grade 3 adenocarcinoma, diagnosed between 2004 and 2012. Logistic and Cox regression analyses were utilized to identify predictors of aCRT use and OS, respectively. Survival analysis was performed with Kaplan Meier and log-rank methods. Propensity score matching was employed to decrease the potential influence of selection bias. A total of 11,746 patients were identified for analysis with 8206 (69.9%) receiving aCRT, and 3540 (30.1%) received aRT. Predictors of aCRT included International Federation of Gynecology and Obstetrics stage II (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.22-1.57), papillary serous (OR, 9.44; 95% CI, 8.22-10.85) or clear cell (OR, 3.21; 95% CI, 2.59-3.97) histology, lymph nodes removed...Continue Reading

References

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Citations

Jun 25, 2019·Current Opinion in Oncology·Günter Emons, Dirk Vordermark
Oct 9, 2019·American Journal of Clinical Oncology·Dustin BootheDavid K Gaffney
Jan 18, 2020·Cancer Chemotherapy and Pharmacology·César Gómez-RaposoEnrique Casado Saenz
Jan 15, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Limor HelpmanLilian Gien
Oct 23, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Nasreen Hag-YahiaLimor Helpman
Mar 21, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Leonid B ReshkoScott R Silva

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