The addition of indomethacin to betamimetics for tocolysis: any benefit for the neonate?

European Journal of Obstetrics, Gynecology, and Reproductive Biology
B Van OvermeireP J Van Reempts

Abstract

To study the influence on the neonate of indomethacin administered to the mother as an additional tocolytic. The neonatal outcome in 76 closely matched low birth weight infants was compared retrospectively: those whose mothers received indomethacin together with betamimetics formed the study group, those whose mothers received only betamimetics formed the control group. There was an increased incidence of respiratory distress syndrome (RDS) in the study group (97% versus 45%; P<0.001), an increased need for surfactant use (68% versus 26%; P<0.001) and increased ventilatory support, and an increased incidence of bronchopulmonary dysplasia (BPD) (47% versus 24%; P=0.03). Gestation could not be prolonged significantly by the addition of indomethacin. Indomethacin as an additional tocolytic agent was associated with an increased incidence of RDS, surfactant use and BPD but did not significantly prolong gestation.

References

Jun 1, 1978·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O GamissansA Edo
May 1, 1978·Journal of Clinical Pharmacology·Z FriedmanE S Vesell
Jul 1, 1992·Journal of Pediatric Surgery·I H Krasna, H Kim
Apr 1, 1991·American Journal of Obstetrics and Gynecology·R E BesingerT R Johnson
Feb 1, 1990·American Journal of Obstetrics and Gynecology·K J MoiseR J Carpenter
Oct 1, 1986·American Journal of Obstetrics and Gynecology·J R Niebyl, F R Witter
Dec 1, 1974·Obstetrics and Gynecology·H ZuckermanI Rubinstein
Aug 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Z KatzH Ben Hur
Feb 1, 1995·The European Respiratory Journal·J HergetZ Slavík
Nov 25, 1993·The New England Journal of Medicine·M E NortonR I Clyman

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Citations

Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·R J Sawdy, P R Bennett
Aug 19, 2015·American Journal of Obstetrics and Gynecology·Amy L HammersAndrew M Kaunitz
Jul 5, 2005·Obstetrics and Gynecology·Shanan M LoeAndrew M Kaunitz
Oct 8, 2005·Biology of the Neonate·Eduardo BancalariAlvaro Gonzalez

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