PMID: 8610631Apr 1, 1996Paper

The addition of tamoxifen to dacarbazine and cisplatin in metastatic malignant melanoma. A phase II trial of the Southwest Oncology Group, (SWOG-8921)

American Journal of Clinical Oncology
L E FlahertyV K Sondak

Abstract

Based on the reports of substantial improvement in the response rate w ith the addition of tamoxifen to a multiagent chemotherapy regimen for metastatic melanoma, Southwest Oncology Group (SWOG)-8921 was initiated. A prior regimen (SWOG-8804) of dacarbazine (DTIC) 750 mg/m(2) i.v. day 1 and cisplatin 100 mg/m(2) day 1 repeated every 3 weeks produced a 13% response rate in patients with metastatic melanoma without brain metastasis. SWOG-8921 using identical chemotherapy and schedule added tamoxifen 10 mg twice daily. There were 55 eligible patients registered, median age 52, with 37 men and 18 women. Fifty (91%) patients had evidence of visceral metastasis at registration. There were 10 responders (2 complete and 8 partial responses) for an 18% response rate (95% CI, 9-31%). The response rate in women was 28% (95% CI, 10-53%; in men, 14% (95% CI, 5-29%). Tamoxifen has produced a small increase in the response rate when added to the present combination and schedule of chemotherapy. Further Phase III trials will be necessary to assess whether there is a statistical advantage to the use of tamoxifen when combined with chemotherapy and whether there are statistical differences between men and women.

References

Sep 1, 1977·Cancer·M E CostanzaN Sedransk
Nov 29, 1979·The New England Journal of Medicine·J Brandman
Feb 11, 1975·Cancer·J J CostanziF C Delaney
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·E F McClayR E Bellet
Aug 20, 1992·The New England Journal of Medicine·G CocconiP Costa
Dec 19, 1990·Journal of the National Cancer Institute·S M LugerD R Vlock
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·J HofmannH H Grunicke
Nov 1, 1971·Clinical Pharmacology and Therapeutics·L NathansonA Schilling
Jun 20, 1981·Lancet·R O MirimanoffN Hunziker
Jan 13, 1984·Biochemical and Biophysical Research Communications·H Y Lam
Sep 1, 1984·The Journal of Dermatologic Surgery and Oncology·C L Day, R A Lew
Jul 1, 1984·European Journal of Cancer & Clinical Oncology·R MandevilleJ P Chausseau
Aug 1, 1993·American Journal of Clinical Oncology·W S FletcherJ R Pancoast

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Citations

Dec 21, 2000·Current Oncology Reports·P A Philip, L E Flaherty
Apr 25, 2006·Annals of Surgery·Charles R ScogginsUNKNOWN Sunbelt Melanoma Trial
Jul 5, 2006·Cancer Research·Takuji MoriDave S B Hoon
Oct 26, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·D NashanA Enk
Oct 5, 2010·International Journal of Dermatology·Julieta Ruiz BeguerieRaúl P Valdez

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