The Additional Contribution of White Matter Hyperintensity Location to Post-stroke Cognitive Impairment: Insights From a Multiple-Lesion Symptom Mapping Study

Frontiers in Neuroscience
Lei ZhaoLin Shi

Abstract

White matter hyperintensities (WMH) are common in acute ischemic stroke patients. Although WMH volume has been reported to influence post-stroke cognition, it is still not clear whether WMH location, independent of acute ischemic lesion (AIL) volume and location, contributes to cognitive impairment after stroke. Here, we proposed a multiple-lesion symptom mapping model that considers both the presence of WMH and AIL to measure the additional contribution of WMH locations to post-stroke cognitive impairment. Seventy-six first-ever stroke patients with AILs in the left hemisphere were examined by Montreal Cognitive Assessment (MoCA) at baseline and 1 year after stroke. The association between the location of AIL and WMH and global cognition was investigated by a multiple-lesion symptom mapping (MLSM) model based on support vector regression (SVR). To explore the relative merits of MLSM over the existing lesion-symptom mapping approaches with only AIL considered (mass-univariate VLSM and SVR-LSM), we measured the contribution of the significant AIL and/or WMH clusters from these models to post-stroke cognitive impairment. In addition, we compared the significant WMH locations identified by the optimal SVR-MLSM model for cognitive ...Continue Reading

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Citations

Oct 24, 2018·Journal of Neurology·Barbara CasollaDidier Leys
Sep 10, 2019·Journal of Neuroscience Research·Sharmila Sagnier, Igor Sibon
Nov 17, 2020·Frontiers in Neurology·Mark R EthertonNatalia S Rost
Jan 8, 2021·Chinese Medical Journal·Alexander Yuk Lun LauVincent Chung Tong Mok
May 28, 2021·Stroke; a Journal of Cerebral Circulation·Natalia S RostUNKNOWN DISCOVERY Investigators

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Software Mentioned

LSM
SVR
CU
MoCA
MLSM
elastix

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