The Adenoids but Not the Palatine Tonsils Serve as a Reservoir for Bacteria Associated with Secretory Otitis Media in Small Children

MSystems
Helena Fagö-OlsenAnders Jensen

Abstract

Acute otitis media (AOM), secretory otitis media (SOM), and acute pharyngotonsillitis are the most frequent reasons for visits to general practitioners, pediatricians, and otolaryngologists. Microbial colonization of the epithelial lining of Waldeyer's lymphatic tissues, consisting of the palatine tonsils, lingual tonsils, adenoids, and Eustachian tube tonsil, is a well-known clinical challenge during infancy due to frequent episodes of upper respiratory tract infections. However, no previous studies have investigated the combined role of the palatine tonsils and the adenoids as a reservoir for pathogens associated with SOM in small children. We analyzed the combined crypt microbiome of the palatine tonsils and adenoids from 14 small children with hyperplasia of the tonsils or adenoids and 14 small children with SOM using 16S rRNA gene pyrosequencing. Our study demonstrated a significant difference between the microbiome of the adenoids and that of the palatine tonsils in the two groups but not between the two anatomical locations within the two groups. In particular, the potential pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were almost exclusively found in the adenoids of both patient ...Continue Reading

References

Jan 1, 1988·Acta Oto-laryngologica·C H SørensenS Holm-Jensen
Jun 1, 1984·European Journal of Clinical Microbiology·D Kuklinska, M Kilian
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·C Kamme, N I Nilsson
Dec 1, 1983·International Journal of Pediatric Otorhinolaryngology·C H Sørensen
Jun 14, 2000·The Laryngoscope·I BrookW Jackson
Sep 18, 2001·The Annals of Otology, Rhinology, and Laryngology·I Brook, K Shah
Mar 8, 2005·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Birgit K van StaajiAnne G M Schilder
May 16, 2006·Journal of Clinical Pathology·A SwidsinskiH Lochs
Sep 20, 2006·Bioinformatics·Luke ShenemanJames A Foster
Jun 4, 2008·The Pediatric Infectious Disease Journal·Alban Le MonnierVincent Couloigner
Oct 2, 2008·Emerging Infectious Diseases·Melinda M PettigrewTasnee Chonmaitree
Aug 12, 2009·Nature Methods·Christopher QuinceWilliam T Sloan
Mar 20, 2010·Environmental Microbiology·Susan M HuseMitchell L Sogin
Jul 14, 2010·Database : the Journal of Biological Databases and Curation·Tsute ChenFloyd E Dewhirst
Feb 11, 2011·Journal of Clinical Microbiology·L NisticoL Hall-Stoodley
Jun 18, 2011·American Journal of Rhinology & Allergy·Michael BenningerJudith R Farrar
Jun 28, 2011·Bioinformatics·Robert C EdgarRob Knight
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Feb 22, 2012·The Journal of Infectious Diseases·Markus HiltyKathrin Mühlemann
Jul 4, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Işıl TaylanHüseyin Dere
Aug 24, 2013·PloS One·James O KistlerWilliam G Wade
Feb 19, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ilaria BrambillaGian Luigi Marseglia
Oct 31, 2014·New Microbes and New Infections·D Creemers-SchildE J Kuijper
Aug 1, 2015·International Journal of Pediatric Otorhinolaryngology·Jake Jervis-BardyRobyn L Marsh
Jun 24, 2016·The Laryngoscope·Chun Ling ChanAlkis James Psaltis
Nov 5, 2016·JAMA Otolaryngology-- Head & Neck Surgery·Chun Ling ChanAlkis James Psaltis

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Citations

Sep 6, 2019·MSphere·Jake Jervis-BardyGeraint B Rogers
Dec 19, 2019·Frontiers in Genetics·Rahul MittalXue Zhong Liu
Sep 6, 2020·Journal of Clinical Medicine·Francesco FolinoSara Torretta
Dec 28, 2019·International Journal of Pediatric Otorhinolaryngology·Robyn L MarshHeidi C Smith-Vaughan
Nov 13, 2020·Clinical and Experimental Otorhinolaryngology·Kyung Soo Kim, Hyun Jin Min
May 18, 2021·Frontiers in Immunology·Lindybeth Sarmiento VarónEloísa I Arana
May 16, 2021·Diagnostic Microbiology and Infectious Disease·Mahmut Tayyar KalciogluSema Karabudak
May 28, 2021·Microbial Pathogenesis·Chien-Chia HuangCheng-Hsun Chiu
Jul 26, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Wei CaoQian Liu
Aug 16, 2021·Pediatrics and Neonatology·Chien-Chia HuangChyi-Liang Chen

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Datasets Mentioned

BETA
PRJNA422760

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

Clearcut
LEfSe
PERMANOVA
mothur
PyroNoise
MEGA
thetaYC
BLAST
iToL
Prism6

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