The adenosine pathway in immuno-oncology.

Nature Reviews. Clinical Oncology
B AllardJ Stagg

Abstract

Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from such treatments. Over the past decade, remarkable progress has been made in the development of 'next-generation' therapeutics in immuno-oncology, with inhibitors of extracellular adenosine (eADO) signalling constituting an expanding class of agents. Induced by tissue hypoxia, inflammation, tissue repair and specific oncogenic pathways, the adenosinergic axis is a broadly immunosuppressive pathway that regulates both innate and adaptive immune responses. Inhibition of eADO-generating enzymes and/or eADO receptors can promote antitumour immunity through multiple mechanisms, including enhancement of T cell and natural killer cell function, suppression of the pro-tumourigenic effects of myeloid cells and other immunoregulatory cells, and promotion of antigen presentation. With several clinical trials currently evaluating inhibitors of the eADO pathway in patients with cancer, we herein review the pathophysiological function of eADO with a focus on effects on antitumour immunity. We also discuss the treatment opportunities, potential limitations and bioma...Continue Reading

References

Jul 15, 1992·The Biochemical Journal·H Zimmermann
Apr 1, 1989·The American Journal of Physiology·G H MöserA Deussen
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T B StromJ P Merrill
Dec 20, 1996·The Journal of Biological Chemistry·E KaczmarekS C Robson
Feb 3, 1997·The Journal of Experimental Medicine·D FerrariF Di Virgilio
Aug 1, 1997·Circulation Research·U K DeckingJ Schrader
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G HaskóC Szabó
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L AirasS Jalkanen
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B JohanssonB B Fredholm
Jan 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Scott H DonaldsonRichard C Boucher
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jozef SpychalaBeverly S Mitchell
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong ZhangDavid W Hoskin
Dec 8, 2004·European Journal of Immunology·Susana MinguetTilman Brummer
Dec 8, 2004·The Journal of Experimental Medicine·Linda F ThompsonSean P Colgan
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Courtney M LappasJoel Linden
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana RaskovalovaElieser Gorelik
Dec 7, 2005·The Journal of Experimental Medicine·Holger K EltzschigSean P Colgan
Jun 20, 2006·British Journal of Pharmacology·Edwin S L ChanBruce N Cronstein
Aug 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Akio OhtaMichail Sitkovsky
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tianqing KongSean P Colgan
Dec 16, 2006·Science·Yu ChenWolfgang G Junger
Mar 31, 2007·Cell Death and Differentiation·B B Fredholm
May 16, 2007·The Journal of Experimental Medicine·Silvia DeaglioSimon C Robson
Dec 8, 2007·Biochimica Et Biophysica Acta·Rafal SadejJozef Spychala
Feb 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhongsheng PengBruce N Cronstein
Mar 1, 2008·Blood·Julio C Morote-GarciaHolger K Eltzschig
Apr 12, 2008·Purinergic Signalling·F KukulskiJ Sévigny
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahide TakedachiLinda F Thompson
Jun 19, 2008·Blood·Sergey V NovitskiyMikhail M Dikov
Jun 24, 2008·Diabetes·Keiichi EnjyojiSimon C Robson
Jul 16, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Balázs CsókaGyörgy Haskó
Aug 21, 2008·Neoplasia : an International Journal for Oncology Research·Sergey RyzhovIgor Feoktistov
Sep 25, 2008·Blood·Holger K EltzschigSean P Colgan
Feb 18, 2009·The Journal of Clinical Investigation·Zhongsheng PengBruce N Cronstein

❮ Previous
Next ❯

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Vanessa D'AntongiovanniLuca Antonioli
Nov 28, 2020·Cell Death & Disease·Jitka FucikovaLorenzo Galluzzi
Jan 9, 2021·Cancer Immunology, Immunotherapy : CII·Pedro RochaLuisa Maren Solis
Dec 20, 2020·Biochemical Pharmacology·Gennady G Yegutkin
Feb 3, 2021·Advances in Nutrition·Philippe IcardMarco Alifano
Dec 29, 2020·Journal for Immunotherapy of Cancer·Roberta TurielloPaolo A Ascierto
Dec 29, 2020·Frontiers in Pharmacology·Roberta TurielloSilvana Morello
Feb 1, 2021·Cellular and Molecular Gastroenterology and Hepatology·Karel P AlcedoNatasha T Snider
Jan 13, 2021·Cancers·Haitang YangSean R R Hall
Feb 18, 2021·Journal of Surgical Oncology·Jessica M KeilsonMichael C Lowe
Mar 2, 2021·Medicinal Research Reviews·Bruna C GalgaroMárcia R Wink
Feb 22, 2021·Human Immunology·Alexey Churov, Galina Zhulai
Mar 7, 2021·International Journal of Molecular Sciences·Rola El SayedAli Shamseddine
Mar 18, 2021·Science Signaling·Altay KoyasCaglar Cekic
Mar 18, 2021·Scientific Reports·Nataliia PetrukKatri S Selander
Aug 14, 2020·Journal of Medicinal Chemistry·Jenna L JeffreyJay P Powers
Mar 28, 2021·European Journal of Medicinal Chemistry·Jingyu ZhangXiaowu Dong
Apr 6, 2021·Molecular Therapy. Methods & Clinical Development·Hannah S NewtonLaura Conforti
Nov 19, 2020·Biochemical Pharmacology·Francesco Di VirgilioMichael Williams
Apr 29, 2021·Signal Transduction and Targeted Therapy·Zhao HuangYong Tang
Oct 5, 2020·Purinergic Signalling·Francesco Di Virgilio
May 26, 2021·Cell Biochemistry and Function·Isabele Cristiana IserMarcia Rosângela Wink
Jun 13, 2021·Trends in Cell Biology·Karel P AlcedoNatasha T Snider
Jun 15, 2021·The EMBO Journal·Oliver KeppLorenzo Galluzzi
Jun 30, 2021·Trends in Cancer·Lin XiaoKlaartje Somers
Jul 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Feiyang JinYongzhong Du
Jul 25, 2021·International Journal of Molecular Sciences·Silvia PasquiniKatia Varani
Jul 31, 2021·Nature Reviews. Clinical Oncology·Dean C SingletonWilliam R Wilson
Nov 21, 2020·ACS Medicinal Chemistry Letters·Constanze C SchmiesChrista E Müller
Aug 28, 2021·Journal of Personalized Medicine·Magis MandapathilTheresa L Whiteside
Aug 24, 2021·Frontiers in Immunology·Valentina AudritoSilvia Deaglio
Sep 12, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Xudong HeJiejie Xu
Oct 9, 2021·Signal Transduction and Targeted Therapy·Kai LiYongsheng Wang
Nov 25, 2021·Nucleosides, Nucleotides & Nucleic Acids·Agata JędrzejewskaRyszard Tomasz Smoleński
Nov 26, 2021·Frontiers in Medicine·Franziska BrauneckWalter Fiedler
Dec 22, 2021·Cancer Metastasis Reviews·E Kenneth ParkinsonMaria E Mycielska
Jan 22, 2022·Journal of Drug Targeting·Negah MahhengamHomayoon Siahmansouri
Jan 27, 2022·Journal of Medicinal Chemistry·Mirko ScortichiniKenneth A Jacobson
Jan 27, 2022·Current Opinion in Oncology·Alix Devaux, Jean-Francois Baurain

❮ Previous
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Methods Mentioned

BETA
nucleotide exchange
RNA-seq
GTPase
biopsy

Clinical Trials Mentioned

NCT03719326
NCT03720678
NCT03846310
NCT03629756
NCT02754141
NCT02403193
NCT02740985
NCT02503774
NCT02655822
NCT03454451

Software Mentioned

GraphPad prism
DESeq2
Xena

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