The Adequacy of Core Biopsy in the Assessment of Smooth Muscle Neoplasms of Soft Tissues: Implications for Treatment and Prognosis

The American Journal of Surgical Pathology
Nina SchneiderKhin Thway

Abstract

The grading of soft tissue sarcomas is one of the most important prognostic factors and determines patient management. Although grading of most adult-type soft tissue sarcomas on biopsies correlates highly with the final grading on the excision specimen, it appears less reliable for tumors of smooth muscle. We assessed the pathologic findings for smooth muscle neoplasms diagnosed by core biopsy at our tertiary sarcoma center, and compared them with those in the subsequent excision specimens. A total of 100 patients with leiomyosarcoma first diagnosed on core biopsy and with a subsequent excision were identified and the accuracy of the biopsy grade determined by comparison with the excision grade. Differences in other salient histologic parameters were also noted. A grade difference between biopsy and excision specimens of leiomyosarcomas was found in 68% of cases, with all these cases showing an increase in grade from biopsy to excision specimen. Of the 3 parameters used for grading using the French Federation of Cancer Centers Sarcoma Group Grading System (FNCLCC), necrosis was the score that most commonly differed between biopsy and excision specimen (55%), closely followed by the mitotic count (51%). The grading of soft tiss...Continue Reading

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Citations

Jan 25, 2019·The British Journal of Surgery·L M AlmondC Morosi
Aug 24, 2019·Annals of Surgical Oncology·Mark Fairweather, Chandrajit P Raut
May 18, 2019·Archives of Pathology & Laboratory Medicine·Kenneth P H Pritzker, Heikki J Nieminen
Sep 11, 2020·International Journal of Surgical Pathology·Michela LibertiniRobin L Jones
Dec 2, 2017·Journal of Surgical Oncology·Christina Messiou, Carlo Morosi
Dec 13, 2017·Journal of Surgical Oncology·Salvatore L Renne, O Hans Iwenofu
Jan 15, 2021·Journal of Surgical Oncology·Suren SubramaniamDavid E Gyorki
Mar 7, 2021·NPJ Precision Oncology·Eve MerryPaul H Huang
Mar 25, 2021·Critical Reviews in Oncology/hematology·Nicolò GennaroWinette T A van der Graaf
Mar 28, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Jasminka Igrec, Michael H Fuchsjäger

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