PMID: 16519401Mar 8, 2006Paper

The adhesive properties of endothelial cells on endovascular stent coated by substrates of poly-l-lysine and fibronectin

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
G X WangR Guidoin

Abstract

Optimizing endothelial cell growth and adhesion on the surface of metallic stents implanted in the vascular system is a fundamental issue in understanding and improving their long-term biocompatibility. The ability of the endothelial cell to attach and adhere to the luminal stent surface as well as the capacity to withstand the significant shear stress associated with blood flow are important determinants. The adhesive characteristics of human umbilical vein endothelial cellsectin (HUVEC) on stent surfaces coated with either Poly-L-Lysine (PLL) or fibron (FN) were compared with uncoated controls. Increasing concentrations of PLL and FN were measured using a micropipette aspiration system. The adhesivenamic properties of HUVECs under static flow conditions were compared to a dy environment on endovascular stents using a parallel-plate-flow chamber. A scanning electron microscope picture was used to measure the number and the adhesive cell ratio as well as the percentage of surface coverage of stent by endothelial cells. The adhesive forces of HUVECs on foreign surfaces coated with PLL and FN were higher compared to uncoated surfaces, and were dependent on incr ing concentrations. These coatings resulted in significant increase o...Continue Reading

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Citations

Jun 12, 2009·International Journal of Nanomedicine·Eli FineThomas J Webster
Oct 16, 2015·Small·Jun Hon PangAlexander M Seifalian
Jun 21, 2011·Colloids and Surfaces. B, Biointerfaces·Y WangI Zhitomirsky
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May 6, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Xianjun WangOlle Inganäs

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