PMID: 3767289Sep 1, 1986Paper

The adjusted serum calcium concept--a reappraisal

Annals of Clinical Biochemistry
J P AshbyM G Rinsler

Abstract

The relationship between serum calcium and albumin was studied using a data base containing biochemical results on approximately 687,000 samples. To exclude patients with established bone, liver and kidney disease, calcium and albumin values had to be accompanied by additional results falling within the laboratory reference range for urea, phosphate, globulin, alkaline phosphatase and aspartate transaminase activities. The regression coefficients of calcium on albumin changed significantly following a change of instrumentation, even though the analytical principles of the methods remained the same. In addition, using standard laboratory methods, the relationship between calcium and albumin deviated from linearity at albumin concentrations less than 30 g/L. Care is needed in the selection and clinical application of factors for the adjustment of serum calcium for changes in the concentration of circulating albumin. Using a large data base, an albumin-related reference range for serum calcium may be calculated, eliminating the need for adjusting calcium values.

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Citations

Nov 29, 2008·BMC Clinical Pathology·Matthew T JamesBrenda R Hemmelgarn
Jul 1, 1997·Computer Methods and Programs in Biomedicine·M HekkingE S Gelsema
Jul 1, 1992·Archives of Gerontology and Geriatrics·A Sorva
Jun 22, 2016·Journal of Clinical Pathology·Jonathan Joseph Scargill, John Mark Guy
Mar 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·J P Ashby, B M Frier
Apr 4, 2015·Annals of Clinical Biochemistry·Sarah L DaviesAnna M Milan
Nov 21, 1997·Annals of Clinical Biochemistry·J P AshbyS M Gow
May 1, 1988·Annals of Clinical Biochemistry·T A Gray, C R Paterson

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