The adjuvant GLA-AF enhances human intradermal vaccine responses

Science Advances
Darrick CarterSteven G Reed

Abstract

Adjuvants are key to shaping the immune response to vaccination, but to date, no adjuvant suitable for human use has been developed for intradermal vaccines. These vaccines could be self-administered and sent through the mail as they do not require long needles or technical expertise in immunization. In the event of a pandemic outbreak, this approach could alleviate the congregation of patients in health centers and thus reduce the potential of these centers to enhance the spread of lethal infection. A reliable and potent vaccine system for self-administration would provide an effective countermeasure for delivery through existing product distribution infrastructure. We report results from preclinical and clinical trials that demonstrate the feasibility of an adjuvanted, intradermal vaccine that induced single shot protection in ferrets and seroprotection in humans against one of the more lethal strains of pandemic flu, Indonesia H5N1. In the human trial, the vaccine was safe and clinical responses were above approvable endpoints for a protective flu vaccine. Inclusion of a modern TLR4 (Toll-like receptor 4) agonist-based adjuvant was critical to the development of the response in the intradermal groups. In humans, this is the ...Continue Reading

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May 21, 2020·Nature Communications·Trevor R F SmithKate E Broderick
Sep 15, 2020·Expert Opinion on Drug Delivery·Emrullah KorkmazLouis D Falo
Feb 5, 2021·Advanced Drug Delivery Reviews·Emrullah KorkmazLouis D Falo
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Aug 29, 2021·Pharmacology & Therapeutics·Pilar Garcia-VelloAntonio Molinaro
Sep 23, 2021·Expert Review of Vaccines·Ruiqi Zhang, Ivan Fan-Ngai Hung

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Methods Mentioned

BETA
enzyme-linked immunosorbent spots
lavages
enzyme-linked immunosorbent assay
chips
pregnancy test

Clinical Trials Mentioned

NCT01657929

Software Mentioned

GraphPad Prism
EMBOSS ( European Molecular Biology Open Software Suite )
GraphPad
Medicago

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