PMID: 6159067Nov 1, 1980Paper

The adjuvant treatment of inoperable stage III and IV epidermoid carcinoma of the head and neck with platinum and bleomycin infusions prior to definitive radiotherapy: an RTOG pilot study

Cancer
J H GlickE Velez-Garcia

Abstract

Twenty-nine previously untreated patients with advanced unresectable Stage III or IV epidermoid carcinoma of the oral cavity, oropharynx, hypopharynx, or nasopharynx were entered on a pilot protocol to evaluate the effectiveness and toxicity of platinum-bleomycin infusion chemotherapy administered prior to definitive radiotherapy. Platinum was given by 24-hour continuous I. V. infusion (in an attempt to decrease gastrointestinal and renal toxicity) without mannitol diuresis at a dose of 80--100 mg/m2 on day 1 and repeated on day 22. Bleomycin was administered 15 U/m2 I. V. push on day 3 and was then followed by a five-day continuous I. V. infusion of 15 U/m2/day. Fourteen of 29 (48%) patients achieved an objective partial response on chemotherapy alone (an additional 5 patients or 17% had a minor response). Chemotherapy was well tolerated with 10/29 experiencing no nausea, 4/29 mild nausea alone, and 14/29 experiencing controllable nausea/vomiting. Transient reversible azotemia was noted in 4, skin rash in 3, and anemia in 9 patients. All 29 patients began radiotherapy on day 28; 25 completed radiotherapy and 12/25 (48%) achieved complete tumor clearance; all 12 are currently free of disease with short follow-up. The radiothera...Continue Reading

Citations

Jan 1, 1987·Cancer Metastasis Reviews·M Al-Sarraf
Jan 1, 1988·Pharmacology & Therapeutics·L E Damon, E C Cadman
Jan 13, 1983·The New England Journal of Medicine·W K Hong, R Bromer
Jan 1, 1984·Acta Radiologica. Oncology·K Ahmad, J V Fayos
Jan 1, 1995·Cancer Investigation·M al-Sarraf, M Hussein
Feb 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J B WeissbergJ J Fischer
Nov 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A VillarM Hernandez
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Clavel, A R Maged Mansour
Jan 1, 1984·Critical Reviews in Oncology/hematology·M Al-Sarraf
Sep 12, 1998·Otolaryngologic Clinics of North America·R A Weisman, K T Robbins
Apr 1, 1988·The Journal of Laryngology and Otology·A KlimaC V Ilberg
May 1, 2010·Expert Opinion on Pharmacotherapy·Missak HaigentzAlfio Ferlito
Nov 5, 1997·American Journal of Clinical Oncology·R S Hughes, E P Frenkel
May 14, 1983·The Medical Journal of Australia·P G GillN D Harvey
Mar 15, 1993·International Journal of Radiation Oncology, Biology, Physics·K J ParisF Albrink

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