The administration of beta carotene to prevent and regress oral carcinoma in the hamster cheek pouch and the associated enhancement of the immune response

Advances in Experimental Medicine and Biology
J L SchwartzD Trickler

Abstract

In the past four years this laboratory has utilized the hamster cheek pouch tumor model to investigate the anticancer activities of antioxidants, such as beta carotene. These molecules, which have exhibited no evidence of toxicity, have been administered systemically (oral ingestion), and locally to the tumor site in the hamster cheek pouch. The results have been either the inhibition of tumor growth, or the regression of tumor. Adjacent to the degenerating tumors a dense inflammatory infiltrate was observed. Specifically, the cytokines, tumor necrosis factor alpha, and beta, have been immunohistochemically localized to the site of regressed oral carcinoma. Recently, liposomes composed of phosphaditylcholine, phosphaditylserine, and phosphodityelanolamine were combined with beta carotene and injected locally to oral squamous cell carcinoma of the hamster. The results indicated that tumor cells accumulated the liposomes and were lysed while normal mucosal cells did not demonstrate this effect. Therefore antioxidants such as beta carotene can be localized to a tumor site, without a toxic response. Future studies on the anticancer activity of the antioxidants need to focus on the cellular and molecular changes produced in the immu...Continue Reading

Citations

Apr 23, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hemantha K AmarasingheSaman Warnakulasuriya
Jan 1, 1993·Nutrition and Cancer·D TricklerJ Schwartz
Feb 22, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J L Schwartz
Jul 26, 2011·Periodontology 2000·Newell W JohnsonA A Hemantha K Amarasinghe
Dec 9, 2003·Journal of Veterinary Internal Medicine·Stefan MassiminoMichael G Hayek
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·C Scully
Dec 7, 2007·Oral Oncology·E VairaktarisE Patsouris

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