The adsorption of heterocyclic aromatic amines by model dietary fibres with contrasting compositions

Chemico-biological Interactions
P J HarrisL R Ferguson

Abstract

It is often recommended that consumption of dietary fibre should in increased to protect against colorectal cancer. However, although more than 95% of dietary fibre is contributed by whole plant cell walls, very little experimental work has been done using whole plant cell walls. These may protect by adsorbing carcinogens, thus lowering their effective concentration in the alimentary tract, and by carrying the carcinogens out of the body in the faeces. However, plant cell walls vary widely in their composition and physical properties, and not all cell walls will necessarily have protective properties. We therefore isolated 4 plant cell-wall preparations with contrasting compositions as models of the types of cell walls that occur in the diet. We investigated the abilities of these preparations to adsorb in vitro 6 heterocyclic aromatic amines (HAAs). HAAs occur in the human diet and several are colon carcinogens, at least in rats. We found that the ability of the HAAs to adsorb to the plant cell walls increased with increasing hydrophobicity of the HAA, measured as the calculated logarithm of the partition coefficient between 1-octanol and water (C logP). A cell-wall preparation containing mainly the walls of parenchyma cells (...Continue Reading

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Citations

Aug 10, 2001·Diseases of the Colon and Rectum·S SenguptaP R Gibson
Mar 1, 2004·Environmental Health and Preventive Medicine·Akio IuchiKeito Boki
May 13, 2004·Toxicology·Lynnette R FergusonNishi Karunasinghe
Apr 11, 2001·Mutation Research·L R Ferguson
Sep 28, 2002·Mutation Research·Lynnette R Ferguson
Oct 20, 1999·Mutation Research·G Santana-Rios, R H Dashwood
Feb 7, 2001·Mutation Research·L R Ferguson, P J Harris
Jul 23, 1999·Mutation Research·P J Harris, L R Ferguson
Jan 5, 2002·Nutrition and Cancer·L R FergusonP J Harris
Feb 26, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eduardo De StefaniMaría Mendilaharsu
May 19, 2006·International Journal of Cancer. Journal International Du Cancer·Alvaro L RoncoMaría Mendilaharsu
Mar 6, 2008·Molecular Nutrition & Food Research·Reinhard StidlSiegfried Knasmüller
Jan 6, 2006·International Journal of Epidemiology·C Mary SchoolingTai Hing Lam
Jul 19, 2017·Journal of the Science of Food and Agriculture·Judith SchäferMirko Bunzel
Aug 17, 2006·Journal of Agricultural and Food Chemistry·B Stephen InbarajB H Chen

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