The adsorption of vancomycin by polyacrylonitrile, polyamide, and polysulfone hemofilters

Artificial Organs
Qi TianApril Wong

Abstract

The aim of this study was to characterize vancomycin adsorption by polyacrylonitrile (PAN), polyamide, and polysulfone hemofilters using an in vitro model of hemofiltration. Vancomycin (36 mg) was added to a blood-crystalloid mixture of known volume (target concentration of 50 mg/L) and pumped around a closed circuit. Adsorption, which was calculated from the fall in concentration over 120 min, was significantly greater by 0.6-m(2) PAN filters (10.08 +/- 2.26 mg) than by 0.6-m(2) polyamide (5.20 +/- 1.82 mg) or 0.7-m(2) polysulfone (4.80 +/- 2.40 mg) filters (P < 0.05). Cumulative adsorption was not changed by the addition of 500-mL lactated Ringer's solution (to reduce the circulating vancomycin concentration). These data show that although adsorption of vancomycin by PAN, polyamide, and polysulfone hemofilters occurs, the absolute adsorption is small. Adsorption is dependent on filter material and is not reversed by a decrease in circulating concentration.

References

Jul 1, 1992·Antimicrobial Agents and Chemotherapy·J M QualeR H Barth
Dec 21, 2000·Critical Care : the Official Journal of the Critical Care Forum·R Bellomo, C Ronco
Aug 28, 2003·Artificial Organs·Bruce A MuellerKevin M Sowinski
Aug 26, 2004·British Journal of Clinical Pharmacology·Megan E DelDotSusan E Tett
Jul 21, 2006·International Journal of Antimicrobial Agents·Qi TianJeff Lipman

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Citations

Dec 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alain FicheuxAngel Argilés
Feb 28, 2009·Artificial Organs·Paul S Malchesky
Feb 15, 2011·Artificial Organs·Masanori AbeKoichi Matsumoto
Mar 5, 2011·Blood Purification·Deborah A PaskoBruce A Mueller

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