The advantages and limits of indium-111 labeling of antibodies. Experimental studies and clinical applications

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
S E Halpern

Abstract

Radiolabeling of antibodies with In-111 has now been accomplished to the point that it is highly reproducible, achieves excellent labeling efficiency, and does not damage the antibody. Use of In-111 for radioimmunodetection is advantageous because of the excellent imaging characteristics of the In-111, moderate radiation dose, ease of labeling, and appropriate half-life. The liabilities of the In-111 method include slightly greater cost of the radionuclide, slow clearance of background sites, and a shelf life requiring it to be ordered on a weekly basis. When all characteristics of the radionuclide are taken into account, it appears to be superior to I-131 for radioimmunoimaging. A controlled study using iodinated and Indium labeled antibodies in the same group of patients needs to be done to accurately access how well the two function for tumor detection.

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C F MearesP J Lavender

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Citations

May 29, 2012·Nanomedicine·Ripen MisriUrs O Häfeli
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·D J Hnatowich
Jul 1, 1989·Seminars in Nuclear Medicine·L S ZuckierM D Scharff
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Mar 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Makiya NishikawaMitsuru Hashida

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