The adverse effects of aldrin and dieldrin on both myometrial contractions and the secretory functions of bovine ovaries and uterus in vitro

Toxicology and Applied Pharmacology
Michał H WrobelJan Kotwica

Abstract

Aldrin and dieldrin are chloroorganic insecticides which are recognised as endocrine disruptors. The aim of the study was to investigate their effect on the secretory functions of the uterus and ovary and on myometrial contractions. Myometrial strips and uterine and ovarian cells from nonpregnant cows were incubated with the xenobiotics (0.1, 1 or 10 ng/ml) for 24 or 72 h. Next, their effect on viability of myometrial, endometrial, granulosa and luteal cells, myometrial strip contractions, the synthesis and secretion of prostaglandins (PGs: PGF2α and PGE2) from uterine cells, the secretion of oestradiol (E2), testosterone (T) and oxytocin (OT) from granulosa cells and the secretion of progesterone (P4) and OT from luteal cells were determined. Neither of the xenobiotics (10 ng/ml) affected (P>0.05) the viability of the ovarian and uterine cells, while both (0.1-10 ng/ml) decreased (P<0.05) the basal and OT-stimulated myometrial contractions. In spite of these effects, neither of the insecticides affected (P>0.05) the synthesis and the secretion of PGs from the myometrial cells. Although they also did not impair the secretion of the PGs from the endometrial cells, they abolished (P<0.05) the stimulatory effect of OT (P<0.05) on ...Continue Reading

References

Oct 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D R JubergR Loch-Caruso
Nov 15, 1984·American Journal of Obstetrics and Gynecology·A R FuchsM S Soloff
Feb 1, 1993·British Journal of Pharmacology·J SeniorJ K Clayton
Oct 1, 1995·Endocrine Reviews·G J Pepe, E D Albrecht
Jan 1, 1996·Reproductive Toxicology·M L TsaiR Loch-Caruso
Aug 14, 1998·Environmental Health Perspectives·K F ArcaroJ F Gierthy
Nov 11, 1999·Toxicology Letters·D E StevensonJ E Klaunig
Dec 29, 1999·Reproductive Toxicology·K A Criswell, R Loch-Caruso
Apr 25, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L C HodgesC L Walker
Mar 8, 2003·Food Additives and Contaminants·S M WaliszewskiR M Infanzón
Oct 28, 2003·Analytical and Bioanalytical Chemistry·Marie-Louise ScippoGuy Maghuin-Rogister
Jun 30, 2004·International Journal of Food Sciences and Nutrition·C ArmendárizR Farré
Jul 21, 2004·Environmental Research·Begoña BotellaNicolás Olea
Nov 10, 2004·Environmental Research·Matthew P LongneckerJohn W Brock
Aug 27, 2005·American Journal of Epidemiology·Scott A VennersXiaobin Wang
Oct 26, 2005·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Sheng Zhao, Russell D Fernald
Sep 21, 2007·Environment International·R McKinlayN Voulvoulis
Oct 22, 2009·Journal of Epidemiology and Community Health·Jarnail Singh ThakurRajesh Kumar
Mar 3, 2010·Environmental Monitoring and Assessment·Md MustafaB D Banerjee
Oct 4, 2012·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Bayessa D Letta, Louis E Attah
Aug 27, 2013·Acta Veterinaria Hungarica·Robert RekawieckiJan Kotwica
Nov 20, 2013·Indian Journal of Endocrinology and Metabolism·Laxmikant R TomarB D Banerjee

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