The AeAct-4 gene is expressed in the developing flight muscles of female Aedes aegypti

Insect Molecular Biology
D MuñozA A James

Abstract

Population reduction of mosquitoes is an effective method for controlling dengue fever and malaria transmission. Recent developments in control techniques include proposals to construct transgenic strains of mosquitoes carrying dominant, conditional-lethal genes under the control of sex- and stage-specific promoters. In order to identify such promoters, subtractive cDNA libraries derived from male and female pupal mRNA of the yellow fever mosquito, Aedes aegypti, were constructed and screened. A cDNA clone, F49, corresponds to a gene expressed specifically in female pupae. Sequence analyses revealed that this gene belongs to the actin gene family, and therefore was designated Aedes Actin-4 (AeAct-4). Transcription analyses demonstrated that this gene is expressed predominantly in the indirect flight muscles and, to a lesser extent, the legs of developing female mosquitoes. The promoter of this gene may be a useful tool for developing conditional lethal strains of mosquitoes.

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Citations

Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Guoliang FuLuke Alphey
Jul 24, 2013·BMC Developmental Biology·Brent W HarkerDavid W Severson
Jul 18, 2012·PLoS Neglected Tropical Diseases·Geneviève M C LabbéLuke Alphey
Nov 11, 2008·Cell Host & Microbe·Olle TereniusAnthony A James
Feb 18, 2017·Insects·Yan-Jang S HuangDana L Vanlandingham
Dec 3, 2015·Anais Da Academia Brasileira De Ciências·Fernanda A Alves-CostaAdriane P Wasko
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Sep 2, 2009·Revista de saúde pública·André Barreto Bruno WilkeMauro Toledo Marrelli
Dec 4, 2020·PLoS Neglected Tropical Diseases·David Navarro-PayáLuke Alphey
Dec 10, 2020·Nature Communications·Ethan C AlleyKevin M Esvelt
Aug 28, 2021·BMC Developmental Biology·Antonio Celestino-MontesFidel de la Cruz Hernández-Hernández

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