The aerolysin nanopore: from peptidomic to genomic applications

Nanoscale
Yong WangKai Tian

Abstract

The aerolysin pore (ARP) is a newly emerging nanopore that has been extensively used for peptide and protein sensing. Recently, several groups have explored the application of ARP in detecting genetic and epigenetic markers. This brief review summarizes the current applications of ARP, progressing from peptidomic to genomic detection; the recently reported site-directed mutagenesis of ARP; and new genomic DNA sensing approaches, and their advantages and disadvantages. This review will also discuss the perspectives and future applications of ARP for nucleic acid sequencing and biomolecule sensing.

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Citations

Jul 17, 2019·Chemical Communications : Chem Comm·Yao LuYi-Tao Long
Apr 11, 2020·Chembiochem : a European Journal of Chemical Biology·Fangzhou HuAihua Zou
Mar 25, 2019·International Journal of Molecular Sciences·Hyunil RyuTae-Joon Jeon
Aug 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cheng-Jie DengYun Zhang
Dec 2, 2020·Angewandte Chemie·Zheng-Li HuYi-Tao Long
Jul 20, 2021·Frontiers in Bioengineering and Biotechnology·Ling Zhi WuLi Xing Weng
Nov 22, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jie YangYi-Tao Long
Jun 27, 2019·Analytical Chemistry·Fu-Na MengYi-Tao Long

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Methods Mentioned

BETA
X-ray
biosensing
biosensors

Software Mentioned

ARP

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