The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Silvana De PirroAldo Badiani

Abstract

Previous studies have shown that individuals with heroin and cocaine addiction prefer to use these drugs in distinct settings: mostly at home in the case of heroin and mostly outside the home in the case of cocaine. Here we investigated whether the context would modulate the affective and neural responses to these drugs in a similar way. First, we used a novel emotional task to assess the affective state produced by heroin or cocaine in different settings, based on the recollections of male and female drug users. Then we used fMRI to monitor neural activity during drug imagery (re-creating the setting of drug use) in male drug users. Consistent with our working hypothesis, the majority of participants reported a shift in the affective valence of heroin from mostly pleasant at home to mostly unpleasant outside the home (p < 0.0001). The opposite shift was observed for cocaine; that is, most participants who found cocaine pleasant outside the home found it unpleasant when taken at home (p < 0.0014). Furthermore, we found a double dissociation, as a function of drug and setting imagery, in BOLD signal changes in the left PFC and caudate, and bilaterally in the cerebellum (all p values <0.01), suggesting that the fronto-striatal-ce...Continue Reading

Citations

Nov 14, 2019·Molecular Psychiatry·Sarah D LichensteinSarah W Yip
Nov 18, 2018·Psychopharmacology·Maria Teresa De LucaAldo Badiani
Jul 3, 2020·Frontiers in Neuroscience·Elizabeth A CrummySusan M Ferguson
Jun 4, 2020·The Journal of International Medical Research·Li Li, Shengyuan Yu
Dec 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jerome A J BeckerJulie Le Merrer
Mar 9, 2021·Social Cognitive and Affective Neuroscience·Nina C Christie
Jul 22, 2019·Biological Psychiatry·Marco VenniroYavin Shaham
Apr 9, 2021·Peptides·Richard J Bodnar
Jun 15, 2021·Frontiers in Psychiatry·James M BjorkF Gerard Moeller
Jul 3, 2021·International Journal of Molecular Sciences·Marek Schwendt, Lori A Knackstedt
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco VenniroYavin Shaham
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahmet O CeceliRita Z Goldstein

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