PMID: 8586376Jul 1, 1995Paper

The afferent circulation of the liver in patients with primary hepatocellular carcinoma

Hepato-gastroenterology
F JakabJ Faller

Abstract

The data on the afferent circulation of the liver, in patients with primary hepatocellular carcinoma, are controversial or non-existent. The authors measured hepatic arterial and portal venous flow intra-operatively by transit time ultrasonic volume flowmetry. In patients with primary hepatocellular carcinoma, the hepatic artery flow increased to 0.55 +/- 0.21 l, as compared with the control value of 0.37 +/- 102 l/min (p < 0.01). The portal venous flow decreased from 0.61 +/- 0.212 l/min to 0.47 +/- 0.203 l/min p < 0.01). Owing to the opposite changes in the afferent circulation, the total hepatic blood flow did not change significantly. The ratio of hepatic arterial flow to portal vein flow increased to 1.239 +/- 0.246 in patients with hepatocellular carcinoma, which is twice the basic control value (0.66 +/- 0.259 l/min). After resection, this ratio showed virtually no change. The surgical intervention, that is resection of the liver, did not significantly alter hepatic artery and portal venous flow, although total hepatic blood flow decreased significantly (p < 0.01). The pronounced increase in the ratio of hepatic arterial flow may be attributed to the decrease in portal venous flow caused by the primary hepatocellular car...Continue Reading

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