PMID: 9185120May 1, 1997Paper

The African polio vaccine-acquired immune deficiency syndrome connection

Medical Hypotheses
V Reinhardt, A Roberts

Abstract

Seroepidemiological, clinical and molecular findings suggest that the acquired immune deficiency syndrome virus human immunodeficiency virus-1 was introduced into the human species at the time (late 1950s) and in the geographic area (Zaire) in which millions of Africans were vaccinated with attenuated poliomyelitis virus strains that were produced in kidney tissue obtained from monkeys. Since monkeys not only harbor viruses that are remarkably similar to and genetically related to human immunodeficiency virus-1, but also served as tissue donors for the African polio vaccine, it is reasonable to suspect that a then non-detectable monkey virus with human-1-like properties was unknowingly co-cultured with the attenuated poliovirus virus and subsequently administered to the vaccinees. The possibility of such a polio vaccine-acquired immune deficiency syndrome connection is a reminder of the unpredictable danger of artifically crossing natural species-barriers in biomedical laboratories.

References

Apr 9, 1992·The New England Journal of Medicine·D J BergsagelR L Garcea
Jun 6, 1992·Lancet·G Lecatsas, J J Alexander
Mar 1, 1992·AIDS Research and Human Retroviruses·G MyersB Korber
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T GojoboriS Yokoyama
Oct 24, 1991·Nature·T LehnerM Chapman
Nov 28, 1991·Nature·C Gilks
Jul 7, 1990·Lancet·G CorbittG Williams
May 24, 1990·Nature·R C Desrosiers
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·Y OhtaM Hayami
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A McClureR F Doolittle
Feb 1, 1988·AIDS·J Schneider, G Hunsmann
Jan 11, 1986·Lancet·R J Biggar
Jul 9, 1988·Lancet·M S WilkesW G Thompson
Oct 1, 1988·Scientific American·M Essex, P J Kanki
Jan 26, 1989·The New England Journal of Medicine·P G Spitzer, N J Weiner
Mar 16, 1985·British Medical Journal·R J BiggarP L Gigase
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M KannagiN L Letvin
Nov 1, 1985·Annals of Internal Medicine·J B Brunet, R A Ancelle
Jan 25, 1986·Medicina clínica·T Pumarola Suñé, C Cordón-Cardó
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P N FultzA Srinivasan
Apr 23, 1987·Nature
Jan 1, 1988·AIDS·R W Ryder, S E Hassig
Jun 7, 1985·Science·M D DanielR C Desrosiers
Nov 1, 1988·Journal of Virology·M D DanielP K Sehgal
Nov 24, 1988·Nature·P M Sharp, W H Li
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·J SonnetG Burtonboy
Jan 1, 1987·Annals of the New York Academy of Sciences·M Alizon, L Montagnier
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K J LuiD J Bregman

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