The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis

FEBS Letters
Bruno HernaezCovadonga Alonso

Abstract

A specific interaction of ASFV p54 protein with 8 kDa light chain cytoplasmic dynein (DLC8) has been previously characterized and this interaction is critical during virus internalization and transport to factory sites. During early phases of infection, the virus induces the initiation of apoptosis triggering activation of caspase-9 and -3. To analyze the role of the structural protein p54 in apoptosis, transient expression experiments of p54 in Vero cells were carried out which resulted in effector caspase-3 activation and apoptosis. Interestingly, p54 mutants, lacking the 13 aa dynein-binding motif lose caspase activation ability and pro-death function of p54. This is the first reported ASFV protein which induces apoptosis.

References

Feb 1, 1996·Virus Research·F RodriguezJ M Escribano
Jun 1, 1997·Virus Research·P Gómez-Puertas, J M Escribano
Jul 30, 1999·Nature Structural Biology·J LiangJ Clardy
Mar 21, 2000·Biochimica Et Biophysica Acta·S M King
Jan 20, 2001·The Journal of Biological Chemistry·K W LoM Zhang
Jan 19, 2002·Journal of Virology·Jodi L Connolly, Terence S Dermody
Oct 9, 2002·Genes & Development·Andrea Cuconati, Eileen White

❮ Previous
Next ❯

Citations

Jun 14, 2005·Trends in Microbiology·Katinka DöhnerBeate Sodeik
Dec 25, 2012·Virus Research·Covadonga AlonsoRaquel Muñoz-Moreno
Nov 10, 2012·Virus Research·Sandra BlomeMartin Beer
Jun 10, 2015·Virus Research·Raquel Muñoz-MorenoCovadonga Alonso
Jul 23, 2011·The FEBS Journal·Javier Merino-GraciaIgnacio Rodríguez-Crespo
Dec 30, 2016·Journal of Virology·Ana Luisa ReisLinda K Dixon
Sep 21, 2019·Transboundary and Emerging Diseases·Teshale TeklueHua-Ji Qiu
Jul 7, 2018·Journal of Veterinary Research·Ning JiaJie Zhang
Nov 20, 2016·Archives of Virology·Sirin TheerawatanasirikulPorntippa Lekcharoensuk
Apr 2, 2020·Journal of Veterinary Science·Dongwan YooHan Sang Yoo
Jun 9, 2020·Frontiers in Veterinary Science·Francisco J Salguero
Jul 19, 2019·Virus Research·Margarida SimõesFernando Ferreira
Sep 14, 2021·Frontiers in Microbiology·Elena RieraYolanda Revilla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis