The age-related changes in the incidence of 'natural' anti-sperm antibodies suggest they are not auto-/isoantibodies

American Journal of Reproductive Immunology : AJRI
Svetoslav KalaydjievLyudmil Nakov

Abstract

Establishing the age-dependent patterns of sperm antibody levels among normal humans. Sera samples from 498 healthy subjects aged 0-97 years - 246 males and 252 females - were tested by the gelatin agglutination test of Kibrick, tray agglutination test of Friberg, sperm immobilization test of Isojima and enzyme-linked immunosorbent assay (ELISA). We found a significant increase in the level of sperm agglutinins after 40 years, which decreased after 88 years. The antibodies detected by ELISA were the highest among prepubertal subjects and also declined with aging. No age-dependent changes were established for the sperm immobilizins. With few exceptions, there were no significant differences between male and female sera, as well as between sera of newborn and their mothers. These data are similar to those established for the age-dependent changes of antibodies towards exogenous antigens, suggesting that the 'naturally occurring' antibodies against human spermatozoa are not auto-/isoantibodies.

References

May 1, 1991·Andrologia·A LenziF Dondero
Jan 1, 1989·Archives of Andrology·S Isojima, K Koyama
Mar 1, 1995·Clinical and Experimental Immunology·M G Wing
Mar 1, 1993·American Journal of Reproductive Immunology : AJRI·R N Fichorova, L S Nakov
Jun 1, 1997·Journal of Reproductive Immunology·C J FlickingerJ C Herr

❮ Previous
Next ❯

Citations

Nov 5, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Esko VeräjänkorvaPasi Pöllänen
Aug 22, 2009·Human Reproduction Update·Gideon A Sartorius, Eberhard Nieschlag
Jul 4, 2009·Archives of Gerontology and Geriatrics·Changsu HanMoon Ho Park
Oct 11, 2005·American Journal of Reproductive Immunology : AJRI·Kadri HallerRaivo Uibo
Aug 9, 2007·Andrologia·S KalaydjievL Nakov
Nov 8, 2007·Reproduction in Domestic Animals = Zuchthygiene·U TaylorH J Schuberth
Dec 17, 2008·Reproduction in Domestic Animals = Zuchthygiene·D RathU Taylor
Nov 9, 2005·Fertility and Sterility·Dimitrina DimitrovaLyudmil Nakov
Jun 20, 2012·Nature Reviews. Urology·Theodore L TollnerGary N Cherr
May 1, 2021·Journal of Clinical Medicine·Artur WdowiakRafał Filip

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.