The aging brain: impact of heavy metal neurotoxicity.

Critical Reviews in Toxicology
Omamuyovwi M IjomoneMichael Aschner

Abstract

The aging process is accompanied by critical changes in cellular and molecular functions, which upset the homeostatic balance in the central nervous system. Accumulation of metals renders the brain susceptible to neurotoxic insults by mechanisms such as mitochondrial dysfunction, neuronal calcium-ion dyshomeostasis, buildup of damaged molecules, compromised DNA repair, reduction in neurogenesis, and impaired energy metabolism. These hallmarks have been identified to be responsible for neuronal injuries, resulting in several neurological disorders. Various studies have shown solid associations between metal accumulation, abnormal protein expressions, and pathogenesis of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and Amyotrophic lateral sclerosis. This review highlights metals (such as manganese, zinc, iron, copper, and nickel) for their accumulation, and consequences in the development of neurological disorders, in relation to the aging brain.

References

Mar 14, 2000·The Journal of Biological Chemistry·D J WaggonerD A Harris
Jun 15, 2000·Environmental Health Perspectives·M Aschner
Jun 1, 2002·Ageing Research Reviews·Jeffrey N KellerQunxing Ding
Jun 28, 2002·Physiological Reviews·Mark P MattsonWenzhen Duan
Nov 28, 2002·The Journal of Comparative Neurology·Changiz GeulaChuang-Kuo Wu
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Michael D GarrickLaura M Garrick
Feb 8, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Joseph R Burdo, James R Connor
Apr 24, 2004·Annals of the New York Academy of Sciences·C W Olanow
Jun 11, 2004·Nature·Tao LuBruce A Yankner
Sep 18, 2004·Trends in Neurosciences·Emil C ToescuPhilip W Landfield
Dec 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woong SunRonald W Oppenheim
Dec 17, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nikolay M FilipovDavid A Lawrence
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric C C CheungRuth S Slack
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Apr 30, 2005·Journal of Cell Science·Gloria SalazarVictor Faundez
May 26, 2005·Progress in Neurobiology·Jason G EmsleyJeffrey D Macklis
Aug 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Michel Goedert
Nov 11, 2005·Journal of Molecular Neuroscience : MN·Armin GieseHans A Kretzschmar
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John C GantOlivier Thibault
Aug 19, 2007·Antioxidants & Redox Signaling·P Hemachandra Reddy
Sep 13, 2007·Biological Trace Element Research·T Lech, J K Sadlik
Sep 18, 2007·Antioxidants & Redox Signaling·Kristina LeunerWalter E Müller
Oct 12, 2007·Medical Hypotheses·Leslie M Klevay
Oct 25, 2008·Biochimica Et Biophysica Acta·Sonia Levi, Ermanna Rovida
Apr 11, 2009·Journal of Neurology·Massimo Pandolfo, Annalisa Pastore
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atul DeshpandeJorge Busciglio
Jul 1, 2009·Experimental Gerontology·Paul HahnJoshua L Dunaief
Jul 28, 2009·Cell·Ravshan BurikhanovVivek M Rangnekar
Aug 4, 2009·Mechanisms of Ageing and Development·Karen M WeidenheimIsabelle Rapin
Oct 15, 2009·Nature Reviews. Neuroscience·Stefano L SensiIsrael Sekler
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul A AdlardAshley I Bush
May 4, 2010·Mechanisms of Ageing and Development·Jinze XuChristiaan Leeuwenburgh
Sep 3, 2010·Journal of Neural Transmission·Robert R CrichtonRoberta J Ward
Oct 22, 2010·Trends in Neurosciences·Orly LazarovHenriette van Praag
Oct 30, 2010·Integrative and Comparative Biology·Quinlyn A SoltowDaniel E L Promislow
Jul 26, 2011·Biochimica Et Biophysica Acta·Hyman M Schipper

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