The aging brain: is function dependent on growth hormone/insulin-like growth factor-1 signaling?

Age
B A Forshee

Abstract

The role of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in normal brain function is not well understood. Studies looking at cognition in humans with GH deficiency have produced controversial results. Experiments in which GH is administered to rodents have shown an apparent improvement in learning and memory. However, studies in which GH deficient or resistant mice were tested in learning and memory tasks reveal that these animals have normal cognitive performance and that their neural function does not deteriorate with age at the same rate as their normal siblings. Further research into this phenomenon revealed that these animals have elevated GH and IGF-1 expression in the hippocampus compared to normal animals. Additional studies with GH deficient and resistant mice suggested that these mutants experience a delay in age-related decline in locomotor activity and exploratory behavior. Data indicate that GH/IGF-1 deficiency and resistance do not impair neural function and instead may offer some degree of protection that results in delayed cognitive and motor aging.

References

Oct 1, 1976·Archives of Disease in Childhood·H C Steinhausen, N Stahnke
Jun 1, 1978·American Journal of Diseases of Children·H F Meyer-BahlburgT Aceto
Nov 1, 1991·Acta Endocrinologica·J O JørgensenJ S Christiansen
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·B Stabler
Jan 1, 1991·Mechanisms of Ageing and Development·D N Khansari, T Gustad
Nov 15, 1990·The New England Journal of Medicine·A L RosenbloomP J Fielder
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R MarcusB M Sherman
Jul 5, 1990·The New England Journal of Medicine·D RudmanD E Mattson
Jul 5, 1990·The New England Journal of Medicine·M L Vance
Jun 1, 1990·Acta paediatrica Scandinavica·H FrischS Singer
Jan 1, 1988·Experimental Gerontology·J Meites
Jan 1, 1987·Acta Paediatrica Scandinavica. Supplement·M B Ranke
Nov 1, 1985·Journal of the American Geriatrics Society·D Rudman
Jul 1, 1984·Child: Care, Health and Development·C S HolmesJ T Hayford
Jan 1, 1982·Schizophrenia Bulletin·D AbbottD J Cohen
Jan 1, 1980·Child Psychiatry and Human Development·D DrotarJ Gotthold
Sep 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·A BartkeD Turyn
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J ForsterR S Sohal
Jan 1, 1996·Hormone Research·A SartorioG Faglia
Apr 1, 1996·Psychoneuroendocrinology·J B DeijenE A van der Veen
Nov 7, 1996·Nature·H M Brown-BorgA Bartke
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y ZhouJ J Kopchick
Jun 10, 1998·Psychoneuroendocrinology·J B DeijenE A van der Veen
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·H B BaumA Klibanski
Nov 21, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D N KaluY Olatunji-Bello
Mar 29, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·P L ThorntonW E Sonntag
Apr 18, 2000·Experimental Gerontology·H M Brown-Borg, S G Rakoczy
May 10, 2000·Free Radical Biology & Medicine·S J Hauck, A Bartke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.