The aging brain: morphomolecular senescence of cortical circuits

Trends in Neurosciences
P R Hof, J H Morrison

Abstract

The human brain is uniquely powerful with respect to cognitive abilities, yet the hippocampal and neocortical circuits that mediate such complex functions are highly vulnerable to aging. Their selective vulnerability is profoundly manifested in Alzheimer's disease (AD), where degeneration of select neurons leads to a near complete loss of cognitive abilities. Most of us will avoid AD as we age. However, many will experience age-associated cognitive impairment - a decline in cognitive status presenting as deficits in memory and key capacities for strategic use of acquired information. Animal studies suggest that both AD and age-associated cognitive impairment reflect vulnerability of the same circuits. However, neuron death predominates in the former, whereas the latter is probably mediated by synaptic alterations in otherwise intact circuits. Fortunately, such age-related synaptic alterations could be reversible, as suggested by recent studies of hormone replacement.

References

Oct 1, 1993·Medical Hypotheses·E MasliahR D Terry
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·A H GazzaleyJ H Morrison
Aug 1, 1996·Journal of Neuropathology and Experimental Neurology·A PetersM S Albert
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·M S Albert
Dec 1, 1996·Brain : a Journal of Neurology·B Anderson, V Rutledge
Jan 1, 1997·Annual Review of Psychology·M Gallagher, P R Rapp
Jul 17, 1997·Nature·C A BarnesB L McNaughton
Oct 23, 1997·Science·J H Morrison, P R Hof
Oct 23, 1997·The Journal of Comparative Neurology·B JacobsM Schall
Feb 24, 1999·Journal of Neuropathology and Experimental Neurology·R MorschP D Coleman
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R B KnowlesB T Hyman
Mar 21, 2000·The Journal of Comparative Neurology·A PetersC Sethares
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J M ConnerM H Tuszynski
Jun 26, 2001·Brain Research. Brain Research Reviews·J Götz
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M M AdamsJ H Morrison
Feb 5, 2002·Annual Review of Physiology·Esther A NimchinskyKarel Svoboda
Mar 14, 2002·The Journal of Biological Chemistry·Daniel A ClaytonMichael D Browning
May 23, 2002·Recent Progress in Hormone Research·Bruce McEwen
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Thomas C Foster, Ashok Kumar
Jan 17, 2003·Journal of Neuropathology and Experimental Neurology·Patrick R HofJohn H Morrison
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey M RedwineFloyd E Bloom
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·John F ReillyFloyd E Bloom
May 2, 2003·The Journal of Comparative Neurology·Yi AiDon M Gash
May 22, 2003·Progress in Neurobiology·Ephron S Rosenzweig, Carol A Barnes
Jun 18, 2003·Neuroscience·A V Savonenko, A L Markowska
Jul 16, 2003·Journal of Neurochemistry·Cathy AndorferPeter Davies
Jul 30, 2003·Genes, Brain, and Behavior·J C DodartS M Paul
Nov 25, 2003·Journal of Neuroscience Research·Robert B Gibbs, Rachel Gabor
Jan 30, 2004·Neurobiology of Aging·Ling BaiKathy R Magnusson
Mar 25, 2004·The American Journal of Pathology·Dennis W Dickson
Mar 25, 2004·The American Journal of Pathology·Christoph SchmitzThomas A Bayer

❮ Previous
Next ❯

Citations

Feb 19, 2013·Brain Structure & Function·Sarah E Crowe, Graham C R Ellis-Davies
May 7, 2013·Pharmacology & Therapeutics·G Jean Harry
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·El MusHenri Tiedge
Nov 5, 2013·Brain Structure & Function·Amy L BauernfeindChet C Sherwood
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chet C SherwoodPatrick R Hof
Jan 15, 2011·International Journal of Alzheimer's Disease·Bernard Weiss
Mar 10, 2010·Brain Structure & Function·Hisaaki TakahashiDara L Dickstein
Nov 19, 2009·Brain Structure & Function·Gregory A ElderPatrick R Hof
Dec 10, 2013·Cell Stem Cell·Justine D MillerLorenz Studer
Jul 6, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dustin R MasserWillard M Freeman
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Emil C Toescu
Feb 8, 2006·Postgraduate Medical Journal·R Peters
Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen D GinsbergElliott J Mufson
Nov 6, 2007·Genes & Development·John A CalarcoBenjamin J Blencowe
Oct 3, 2008·Neuropsychiatric Disease and Treatment·Bernhard J Schaller
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Milos Cekic, Donald G Stein
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik B BlossJohn H Morrison
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gregorio ValdezJoshua R Sanes
Oct 5, 2010·PloS One·Rahul S DesikanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 6, 2011·Age·K M Mehedi HasanMahbub E Sobhani
Oct 25, 2011·Development and Psychopathology·Dario Maestripieri, Christy L Hoffman
Jan 13, 2012·Journal of Neurophysiology·Nadezhda V Povysheva, Jon W Johnson
Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ferenc Deak, William E Sonntag
Jun 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Agenor LimonRicardo Miledi
Jan 30, 2013·PloS One·Hsiao-Lan Sharon WangEin-Yiao Shen
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefania PredaMario Marchi
Jun 17, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John D ElsworthRobert H Roth
Jul 15, 2006·Journal of Cognitive Neuroscience·K SchiltzE Düzel
Nov 4, 2010·Indian Journal of Pathology & Microbiology·S K Shankar
Sep 7, 2006·Biogerontology·Lihong ZhangDavid T Yew
Feb 14, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Shiping MaXiaoliang Wang
Apr 14, 2012·Journal of Aging Research·Roberta SempriniAlessandro Martorana
Jun 11, 2005·Mechanisms of Ageing and Development·João Pedro de Magalhães, Anders Sandberg
Apr 6, 2005·Trends in Neurosciences·Berislav V Zlokovic
Jul 20, 2012·International Psychogeriatrics·Walter E MüllerKristina Leuner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

© 2021 Meta ULC. All rights reserved